Associations of multiple hydroxy-polycyclic aromatic hydrocarbons with serum levels of lipids in the workers from coking and non-ferrous smelting industries

被引：0

作者：

Yu, Hang ^{[2
]}

Chen, Li ^{[3
]}

Chen, Dongming ^{[1
,2
]}

Gao, Yanpeng ^{[1
,2
]}

Li, Guiying ^{[1
,2
]}

Shen, Xiantao ^{[3
]}

Xu, Shunqing ^{[3
]}

An, Taicheng ^{[1
,2
]}

机构：

[1] Guangdong Univ Technol, Inst Environm Hlth & Pollut Control, Guangdong Hong Kong Macao Joint Lab Contaminants E, Guangdong Key Lab Environm Catalysis & Hlth Risk C, Hong Kong 510006, Guangdong, Peoples R China

[2] Guangdong Univ Technol, Sch Environm Sci & Engn, Guangzhou Key Lab Environm Catalysis & Pollut Cont, Key Lab City Cluster Environm Safety & Green Dev,D, Guangzhou 510006, Peoples R China

[3] Huazhong Univ Sci & Technol, State Key Lab Environm Hlth Incubat,Minist Educ, Key Lab Environm & Hlth Wuhan,Tongji Med Coll,Sch, Minist Environm Protect,Key Lab Environm & Hlth Wu, Wuhan 430030, Hubei, Peoples R China

来源：

JOURNAL OF HAZARDOUS MATERIALS | 2024年 / 473卷

基金：

中国博士后科学基金;

关键词：

Hydroxy-polycyclic aromatic hydrocarbons; Lipid profiles; Coking worker; Non-Ferrous metal smelting worker; Co-exposure; EXPOSURE; METABOLITES; GROUNDWATER; PAHS;

D O I：

10.1016/j.jhazmat.2024.134664

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Epidemiological evidence indicates that exposure to polycyclic aromatic hydrocarbons (PAHs) is associated with certain metabolic diseases. However, the relationship between PAHs and serum lipid profiles in exposed subjects remain unknown. Herein, the associations of multiple (8) urinary hydroxylated PAHs (OH-PAHs) in workers of coking (n = 655) and non-ferrous smelting (n = 614) industries with serum lipid levels (marking lipid metabolism) were examined. Multivariable linear regression, Bayesian kernel machine regression, and quantile g computation were used. Most urinary OH-PAHs were significantly higher ( p < 0.001) in coking workers than in non-ferrous smelting workers. In workers of both industries, OH-PAH exposure was associated with elevated levels of serum total cholesterol, total triglyceride, and low -density lipoprotein, as well as reduced high -density lipoprotein levels. Specifically, urinary 4-hydroxyphenanthrene was significantly positively associated with serum total cholesterol, total triglyceride, and low -density lipoprotein levels in non-ferrous smelting workers; however, the completely opposite association of 4-hydroxyphenanthrene with these lipid levels was observed in coking workers. The results of this pioneering examination suggest that exposure to OH-PAHs may contribute to dyslipidemia in coking and non-ferrous smelting workers, and distinct patterns of change were observed. Further prospective studies involving larger sample sizes are needed to further validate the findings.

引用

页数：10