The role of branched-chain amino acids and their downstream metabolites in mediating insulin resistance

被引:1
|
作者
Abdualkader, Abdualrahman Mohammed [1 ,2 ,3 ]
Karwi, Qutuba G. [4 ]
Lopaschuk, Gary D. [5 ]
Al Batran, Rami [1 ,2 ,3 ]
机构
[1] Univ Montreal, Fac Pharm, Montreal, PQ, Canada
[2] Montreal Diabet Res Ctr, Montreal, PQ, Canada
[3] Cardiometab Hlth Diabet & Obes Res Network, Montreal, PQ, Canada
[4] Mem Univ Newfoundland, Fac Med, Div Biomed Sci, St John, NF, Canada
[5] Univ Alberta, Mazankowski Alberta Heart Inst, Edmonton, AB, Canada
关键词
BCAAs; BCKAs; obesity; insulin resistance; type; 2; diabetes; DIET-INDUCED OBESITY; LEUCINE SUPPLEMENTATION; GLUCOSE-METABOLISM; DECREASED CONSUMPTION; INBORN-ERRORS; CATABOLISM; PLASMA; SENSITIVITY; ENZYME; MICE;
D O I
10.3389/jpps.2024.13040
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Elevated levels of circulating branched-chain amino acids (BCAAs) and their associated metabolites have been strongly linked to insulin resistance and type 2 diabetes. Despite extensive research, the precise mechanisms linking increased BCAA levels with these conditions remain elusive. In this review, we highlight the key organs involved in maintaining BCAA homeostasis and discuss how obesity and insulin resistance disrupt the intricate interplay among these organs, thus affecting BCAA balance. Additionally, we outline recent research shedding light on the impact of tissue-specific or systemic modulation of BCAA metabolism on circulating BCAA levels, their metabolites, and insulin sensitivity, while also identifying specific knowledge gaps and areas requiring further investigation. Finally, we summarize the effects of BCAA supplementation or restriction on obesity and insulin sensitivity.
引用
收藏
页数:13
相关论文
共 50 条
  • [1] The contradictory role of branched-chain amino acids in lifespan and insulin resistance
    Yao, He
    Li, Kai
    Wei, Jie
    Lin, Yajun
    Liu, Yinghua
    [J]. FRONTIERS IN NUTRITION, 2023, 10
  • [2] The Emerging Role of Branched-Chain Amino Acids in Insulin Resistance and Metabolism
    Yoon, Mee-Sup
    [J]. NUTRIENTS, 2016, 8 (07)
  • [3] Insulin resistance and the metabolism of branched-chain amino acids
    Jingyi Lu
    Guoxiang Xie
    Weiping Jia
    Wei Jia
    [J]. Frontiers of Medicine, 2013, 7 : 53 - 59
  • [4] THE ROLE OF BRANCHED-CHAIN KETO ACIDS IN MEDIATING INSULIN RESISTANCE IN THE FAILING HEART
    Karwi, Qutuba
    Wagg, Cory
    Zhang, Liyan
    Ussher, John
    Lopaschuk, Gary
    [J]. HEART, 2021, 107 : A173 - A174
  • [5] Insulin resistance and the metabolism of branched-chain amino acids
    Lu, Jingyi
    Xie, Guoxiang
    Jia, Weiping
    Jia, Wei
    [J]. FRONTIERS OF MEDICINE, 2013, 7 (01) : 53 - 59
  • [6] Insulin resistance and the metabolism of branched-chain amino acids in humans
    María M. Adeva
    Jesús Calviño
    Gema Souto
    Cristóbal Donapetry
    [J]. Amino Acids, 2012, 43 : 171 - 181
  • [7] Branched-chain amino acids in metabolic signalling and insulin resistance
    Christopher J. Lynch
    Sean H. Adams
    [J]. Nature Reviews Endocrinology, 2014, 10 : 723 - 736
  • [8] Branched-chain amino acids in metabolic signalling and insulin resistance
    Lynch, Christopher J.
    Adams, Sean H.
    [J]. NATURE REVIEWS ENDOCRINOLOGY, 2014, 10 (12) : 723 - 736
  • [9] Insulin resistance and the metabolism of branched-chain amino acids in humans
    Adeva, Maria M.
    Calvino, Jesus
    Souto, Gema
    Donapetry, Cristobal
    [J]. AMINO ACIDS, 2012, 43 (01) : 171 - 181
  • [10] Genetic Support for a Causal Role of Insulin Resistance on Circulating Branched-Chain Amino Acids and Inflammation
    Wang, Qin
    Holmes, Michael V.
    Smith, George Davey
    Ala-Korpela, Mika
    [J]. DIABETES CARE, 2017, 40 (12) : 1779 - 1786