Methyl Pyruvate Oxime as a Carbonyl Synthon: Synthesis of Ureas, Carbamates, Thiocarbamates, and Anilides

被引：0

作者：

Kim, Seo Yeon ^{[1
]}

Lim, Hee Nam ^{[1
]}

机构：

[1] Yeungnam Univ, Dept Chem, Gyongsan 38541, Gyeongbuk, South Korea

来源：

ORGANIC LETTERS | 2024年 / 26卷 / 18期

基金：

新加坡国家研究基金会;

关键词：

CATALYZED CARBONYLATION; UNSYMMETRICAL UREAS; PRACTICAL SYNTHESIS; AMINES; ACIDS; MILD; CO2;

D O I：

10.1021/acs.orglett.4c01007

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new strategy for the synthesis of unsymmetrical ureas, carbamates, thiocarbamates, and anilides was developed with methyl pyruvate oxime as the carbonyl synthon. The intrinsic reactivity of the reagent enabled consecutive disubstitution involving direct amidation and one-pot deoximative substitution with various nucleophiles. The utility of the method was demonstrated with the synthesis of bioactive molecules.

引用

页码：3850 / 3854

页数：5

共 23 条

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