Sharks give a handle to potent anti-tumor multiparatopic antibodies inducing membrane depletion of PD-L1

Despite the immense clinical success of the antibody therapeutics that neutralize programmed death receptor ligand 1 (PD -L1) and thus resurrect T cell antitumor activity, the patient response rates remain low. In this issue of Cell Chemical Biology , Ludwig et al. 1 reveal novel topologies of multiparatopic antibodies that mediate potent PD -L1 downregulation.