Protein Kinase C Beta II Inhibitor Conjugated with Myristic Acid and Trans-Activator of Transcription improves intracellular delivery and cardiovascular protection in porcine myocardial ischemia/reperfusion injury

被引:0
|
作者
Melnik, Juliet
Ramsarran, James
Clair, Logan
Tanoh, Desmond Boakye
Dang, Jennifer
机构
关键词
D O I
10.1152/physiol.2024.39.S1.2575
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
引用
收藏
页数:2
相关论文
共 10 条
  • [1] Protein Kinase C Beta II Inhibitor Provides Cardiovascular Protection When Combined With Conjugated Myristic Acid and Trans-Activator of Transcription in Porcine Ischemia-Reperfusion Injury
    Harrell, Kayla P.
    Nair, Arjun
    Tanoh, Desmond Boakye
    Singh, Sunit
    Andrews, Emily
    Dean, Tameka
    Chen, Qian
    Barsotti, Robert
    Young, Lindon
    CIRCULATION, 2022, 146
  • [2] Dual Myristic Acid And Trans Activator Of Transcription Conjugated Peptide Facilitates Delivery Of Protein Kinase C Beta II Peptide Inhibitor To Attenuate Myocardial Ischemia/Reperfusion Injury
    Clair, Logan
    Ramsarran, James
    Augustin, Taurai
    Stinson, Cameron
    Dean, Tameka
    Chen, Qian
    Barsotti, Robert
    Young, Lindon
    CIRCULATION RESEARCH, 2022, 131
  • [3] Myristic Acid-Trans-Activator of Transcription Dual Conjugation Improves Intracellular Delivery of Protein Kinase C Beta II Peptide Inhibitor Cargo in Isolated Rat Polymorphonuclear Leukocytes
    Singh, Sunit G.
    Verwoert, Alexis
    Nair, Arjun
    Johnson, Devani
    Humayun, Annam
    Clair, Logan
    DiLisi, Taylor
    Harrell, Kayla
    Dean, Tameka
    Chen, Qian
    Barsotti, Robert
    Young, Lindon
    FASEB JOURNAL, 2022, 36
  • [4] Myristic Acid Conjugated Protein Kinase C Beta II Peptide Inhibitor Elicits Robust Cardioprotective Effects in Rat Myocardial Ischemia-Reperfusion Injury
    Baker, Alison M.
    Beale, Melinda
    Metellus, Daphne
    Madison, Ian
    Singh, Sunit
    Castro, Jeremy
    Lloyd, Michael
    Gjoka, Redona
    Martorana, Rose
    McIntyre, Anahi
    Dang, Jennifer
    Humayun, Annam
    Dean, Tameka
    Chen, Qian
    Barsotti, Robert
    Young, Lindon
    CIRCULATION RESEARCH, 2020, 127
  • [5] Enhancing intracellular delivery of protein kinase C beta II peptide inhibitor using myristic acid-trans-activator of transcription via N-terminus conjugation in isolated rat polymorphonuclear leukocytes
    Dang, Jennifer
    Barrera, Alexandra
    Pinto, Denise
    Verwoert, Alexis
    Singh, Sunit
    PHYSIOLOGY, 2024, 39
  • [6] Myristic Acid Conjugation Itself is Not Responsible for Robust Cardioprotective Effects Observed with Protein Kinase C Beta II Peptide Inhibitor in Ischemia-Reperfusion Injury
    Beale, Melinda
    Madison, Ian
    Metellus, Daphne
    Castro, Jeremy
    Lloyd, Michael
    Gjoka, Redona
    Martorana, Rose
    McIntyre, Anahi
    Dang, Jennifer
    Dean, Tameka
    Chen, Qian
    Barsotti, Robert
    Young, Lindon
    FASEB JOURNAL, 2020, 34
  • [7] Protein Kinase C Beta II Peptide Inhibitor Elicits Robust Effects on Attenuating Myocardial Ischemia/Reperfusion Injury
    Metellus, Daphne
    Lipscombe, Christina
    Ebo, Chinyere
    Nair, Arjun
    Patel, Harsh
    Humayun, Annam
    Michaels, Megan
    Dang, Jennifer
    Finnegan, Matthew
    Checchio, Lucy
    Muftau-Lediju, Faosat
    Martorana, Rose M.
    Chen, Qian
    Barsotti, Robert
    Young, Lindon
    FASEB JOURNAL, 2019, 33
  • [8] Comparing the Efficacy of Pharmacological Preconditioning with Myristic Acid-conjugated, TAT- conjugated and Native Protein Kinase C Epsilon Peptide Activator in Myocardial Ischemia/Reperfusion (MI/R) Models
    McIntyre, Anahi
    Kim, Hanna
    Finnegan, Matthew
    Amuquandoh, Kevin
    Chen, Qian
    Barsotti, Robert
    Young, Lindon
    FASEB JOURNAL, 2018, 32 (01):
  • [9] Protein Kinase C Beta II Peptide Inhibitor Elicits Potent Cardioprotective Effects on Attenuating Ischemia/Reperfusion Injury
    Dang, Jennifer
    Metellus, Daphne
    Lipscomb, Christina
    Ebo, Chinyere
    Nair, Arjun
    Patel, Harsh
    Humayun, Annam
    Michaels, Megan
    Finnegan, Matthew
    Dean, Tameka
    Checchio, Lucy
    Muftau-Lediju, Faosat
    Martorana, Rose M.
    Mcintyre, Anahi
    Chen, Qian
    Barsotti, Robert
    Young, Lindon
    CIRCULATION, 2019, 140
  • [10] Myristoylated Protein Kinase C Beta II Inhibitor Attenuates Renal Injury in Mice Subjected to Severe Bilateral Ischemia-Reperfusion
    Shah, Lisa
    Johnson, Devani
    Verwoert, Alexis B.
    Singh, Sunit G.
    Dean, Tameka C.
    Chen, Qian
    Barsotti, Robert
    Jiang, Yanlin
    George, James
    Agarwal, Anupam
    Yong, Lindon
    FASEB JOURNAL, 2022, 36