Role and analysis of monocyte subsets in cardiovascular disease Joint consensus document of the European Society of Cardiology (ESC) Working Groups "Atherosclerosis & Vascular Biology" and "Thrombosis"

被引：113

作者：

Weber, Christian ^{[1
,2
]}

Shantsila, Eduard ^{[3
]}

Hristov, Michael ^{[1
]}

Caligiuri, Giuseppina ^{[4
]}

Guzik, Tomasz ^{[5
,6
]}

Heine, Gunnar H. ^{[7
]}

Hoefer, Imo E. ^{[8
,9
]}

Monaco, Claudia ^{[10
]}

Peter, Karlheinz ^{[11
]}

Rainger, Ed ^{[3
]}

Siegbahn, Agneta ^{[12
]}

Steffens, Sabine ^{[1
,2
]}

Wojta, Johann ^{[13
]}

Lip, Gregory Y. H. ^{[3
]}

机构：

[1] Univ Munich, Inst Cardiovasc Prevent, Munich, Germany

[2] Partner Site Munich Heart Alliance, German Ctr Cardiovasc Res, Munich, Germany

[3] Univ Birmingham, Inst Cardiovasc Sci, City Hosp, Birmingham, W Midlands, England

[4] Hop Xavier Bichat, INSERM, Paris, France

[5] Jagiellonian Univ, Krakow, Poland

[6] Univ Glasgow, Glasgow, Lanark, Scotland

[7] Univ Saarland, Med Ctr, Dept Internal Med 4, Homburg, Germany

[8] UMC Utrecht, Lab Expt Cardiol, Utrecht, Netherlands

[9] UMC Utrecht, Lab Clin Chem & Hematol, Utrecht, Netherlands

[10] Univ Oxford, Oxford, England

[11] Baker IDI Heart & Diabet Inst, Atherothrombosis & Vasc Biol, Melbourne, Vic, Australia

[12] Uppsala Univ, Clin Chem, Dept Med Sci, Uppsala, Sweden

[13] Med Univ Vienna, Core Facil, Dept Internal Med 2, Vienna, Austria

来源：

THROMBOSIS AND HAEMOSTASIS | 2016年 / 116卷 / 04期

关键词：

Atherosclerosis; leukocyte function / activation; monocytes; CORONARY-ARTERY-DISEASE; CD14(+) CD16(+) MONOCYTES; BLOOD MONOCYTES; GENE-EXPRESSION; CD14(++)CD16(+) MONOCYTES; CD14++CD16+ MONOCYTES; PLATFORM ASSAY; TISSUE FACTOR; MARKERS; CELLS;

D O I：

10.1160/TH16-02-0091

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Monocytes as cells of the innate immunity are prominently involved in the development of atherosclerotic lesions. The heterogeneity of blood monocytes has widely been acknowledged by accumulating experimental and clinical data suggesting a differential, subset-specific contribution of the corresponding subpopulations to the pathology of cardiovascular and other diseases. This document re-evaluates current nomenclature and summarises key findings on monocyte subset biology to propose a consensus statement about phenotype, separation and quantification of the individual subsets.

引用

页码：626 / 637

页数：12

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