A Gain-of-Function mutation in TRPM4 enhances DNFB-induced hypersensitivity via upregulated DC activities

被引:0
|
作者
Wu, X. [1 ]
Wei, D. [1 ]
Tian, Y. [2 ]
Zheng, J. [2 ]
Hwang, S. [1 ]
机构
[1] Univ Calif Davis, Dermatol, Sacramento, CA USA
[2] Univ Calif Davis, Physiol & Membrane Biol, Davis, CA USA
关键词
D O I
暂无
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
744
引用
收藏
页码:S130 / S130
页数:1
相关论文
共 10 条
  • [1] Gain-of-function of TRPM4 predisposes mice to psoriasiform dermatitis
    Yamada, Daisuke
    Vu, Simon
    Wu, Xuesong
    Shi, Zhenrui
    Morris, Desiree
    Bloomstein, Joshua D.
    Huynh, Mindy
    Zheng, Jie
    Hwang, Samuel T.
    FRONTIERS IN IMMUNOLOGY, 2022, 13
  • [2] Theoretical Investigation of the Mechanism by which A Gain-of-Function Mutation of the TRPM4 Channel Causes Conduction Block
    Hu, Yaopeng
    Li, Qin
    Shen, Yanghua
    Fujita, Takayuki
    Zhu, Xin
    Inoue, Ryuji
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (16)
  • [3] Gain-Of-Function Mutationsin TRPM4 Activation Gate Cause Skin Disease PSEK
    Wang, Huijun
    Xu, Zhe
    Lee, Bo Hyun
    Vu, Simon
    Hu, Linghan
    Lee, Mingyang
    Bu, Dingfang
    Cao, Xu
    Hwang, Samuel
    Yang, Yong
    Zheng, Jie
    Lin, Zhimiao
    BIOPHYSICAL JOURNAL, 2019, 116 (03) : 452A - 452A
  • [4] Gain-of-Function Mutations in TRPM4 Activation Gate Cause Progressive Symmetric Erythrokeratodermia
    Wang, Huijun
    Xu, Zhe
    Lee, Bo Hyun
    Vu, Simon
    Hu, Linghan
    Lee, Mingyang
    Bu, Dingfang
    Gao, Xu
    Hwang, Samuel
    Yang, Yong
    Zheng, Jie
    Lin, Zhimiao
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2019, 139 (05) : 1089 - 1097
  • [5] Gain-of-Function Mutations in TRPM4 Cause Autosomal Dominant Isolated Cardiac Conduction Disease
    Liu, Hui
    El Zein, Loubna
    Kruse, Martin
    Guinamard, Romain
    Beckmann, Alf
    Bozio, Andre
    Kurtbay, Gueven
    Megarbane, Andre
    Ohmert, Iris
    Blaysat, Gerard
    Villain, Elisabeth
    Pongs, Olaf
    Bouvagnet, Patrice
    CIRCULATION-CARDIOVASCULAR GENETICS, 2010, 3 (04) : 374 - U326
  • [6] Glibenclamide ameliorates skin inflammation in a TRPM4 gain-of-function murine model of imiquimod-mediated psoriasiform dermatitis
    Yamada, D.
    Vu, S.
    Wu, X.
    Shi, Z.
    Huynh, M.
    Zheng, J.
    Hwang, S. T.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2022, 142 (08) : S82 - S82
  • [7] Aberrant Deactivation-Induced Gain of Function in TRPM4 Mutant Is Associated with Human Cardiac Conduction Block
    Xian, Wenying
    Hui, Xin
    Tian, Qinghai
    Wang, Hongmei
    Moretti, Alessandra
    Laugwitz, Karl-Ludwig
    Flockerzi, Veit
    Ruppenthal, Sandra
    Lipp, Peter
    CELL REPORTS, 2018, 24 (03): : 724 - 731
  • [8] p53 Gain-of-Function Mutation Induces Metastasis via BRD4-Dependent CSF-1 Expression
    Efe, Gizem
    Dunbar, Karen J.
    Sugiura, Kensuke
    Cunningham, Katherine
    Carcamo, Saul
    Karaiskos, Spyros
    Tang, Qiaosi
    Cruz-Acuna, Ricardo
    Resnick-Silverman, Lois
    Peura, Jessica
    Lu, Chao
    Hasson, Dan
    Klein-Szanto, Andres J.
    Taylor, Alison M.
    Manfredi, James J.
    Prives, Carol
    Rustgi, Anil K.
    CANCER DISCOVERY, 2023, 13 (12) : 2632 - 2651
  • [9] Gain-of-Function p53N236S Mutation Drives the Bypassing of HRasV12-Induced Cellular Senescence via PGC-1α
    Yang, Hao
    Zhang, Ke
    Guo, Yusheng
    Guo, Xin
    Hou, Kailong
    Hou, Jing
    Luo, Ying
    Liu, Jing
    Jia, Shuting
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (04)
  • [10] (E)-phenethyl 3-(3,5-dihydroxy-4-isopropylphenyl) acrylate gel improves DNFB-induced allergic contact hypersensitivity via regulating the balance of Thl/Th2/Th17/Treg cell subsets
    Bian, Ruyu
    Tang, Jianlin
    Hu, Lanlan
    Huang, Xuejia
    Liu, Ming
    Cao, Wenxuan
    Zhang, Huijing
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2018, 65 : 8 - 15