Activated STING-containing R-EVs from iPSC-derived MSCs promote antitumor immunity

被引：3

作者：

Qian, Linxia ^{[1
,2
]}

Zhang, Zhonghan ^{[1
]}

Zhang, Ruhua ^{[1
]}

Zheng, Xueping ^{[1
]}

Xiao, Beibei ^{[1
]}

Zhang, Xiaomin ^{[1
]}

Wu, Yuanzhong ^{[1
]}

Chen, Yang ^{[3
]}

Zhang, Xingding ^{[2
]}

Zhou, Penghui ^{[1
]}

Fu, Qingling ^{[4
]}

Kang, Tiebang ^{[1
]}

Gao, Ying ^{[1
]}

机构：

[1] Sun Yat sen Univ, Guangdong Prov Clin Res Ctr Canc, State Key Lab Oncol South China, Canc Ctr, Guangzhou 510060, Guangdong, Peoples R China

[2] Sun Yat sen Univ, Shenzhen Campus Sun Yat sen Univ, Sch Med, Shenzhen 518107, Guangdong, Peoples R China

[3] Southern Med Univ, Stomatol Hosp, Dept Endodont, Guangzhou 510000, Guangdong, Peoples R China

[4] Sun Yat sen Univ, Otorhinolaryngol Hosp, Affiliated Hosp 1, Guangzhou 510080, Guangdong, Peoples R China

来源：

CANCER LETTERS | 2024年 / 597卷

基金：

中国国家自然科学基金; 国家重点研发计划; 中国博士后科学基金;

关键词：

Mesenchymal stem cells; RAB22A; STING; Rafeesome; Extracellular vesicles; Antitumor immunity; MESENCHYMAL STROMAL CELLS; EXTRACELLULAR VESICLES; INTERNATIONAL-SOCIETY; BONE-MARROW; CANCER; MULTICENTER; COMBINATION; PACLITAXEL; SECRETOME; DELIVERY;

D O I：

10.1016/j.canlet.2024.217081

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We recently revealed that activated STING is secreted into RAB22A-induced extracellular vesicles (R-EVs) and promotes antitumor immunity in cancer cells. Whether mesenchymal stem cell (MSC)-derived R-EVs containing activated STING can be used as a novel antitumor immunotherapy remains unclear, as MSC-derived EVs are promising cell-free therapeutics due to their superior biocompatibility and safety, as well as low immunogenicity. Here, we report that induced pluripotent stem cell (iPSC)-derived MSCs can generate R-EVs with a size and mechanism of formation that are similar to those of R-EVs produced from cancer cells. Furthermore, these MSCderived R-EVs containing activated STING induced IFN beta expression in recipient THP-1 monocytes and antitumor immunity in mice. Our findings reveal that the use of MSC-derived R-EVs containing activated STING is a promising cell-free strategy for antitumor immunity.

引用

页数：11

共 1 条

[1] DNA-Containing Exosomes Derived from Cancer Cells Treated with Topotecan Activate a STING- Dependent Pathway and Reinforce Antitumor Immunity
Kitai, Yuichi
Kawasaki, Takumi
Sueyoshi, Takuya
Kobiyama, Kouji
Ishii, Ken J.
Zou, Jian
Akira, Shizuo
Matsuda, Tadashi
Kawai, Taro
JOURNAL OF IMMUNOLOGY, 2017, 198 (04): : 1649 - 1659

← 1 →