Pre-graft vaccination or infection do not decrease COVID-19 infections in recipients of allogeneic stem cell transplantation vaccinated and/or protected by immunotherapy after transplant

被引:0
|
作者
Letailleur, Valentin [1 ]
Le Bourgeois, Amandine [1 ]
Guillaume, Thierry [1 ,2 ]
Garnier, Alice [1 ]
Peterlin, Pierre [1 ]
Jullien, Maxime [1 ]
Antier, Chloe [1 ]
Bene, Marie-Christine [3 ]
Chevallier, Patrice [1 ,2 ]
机构
[1] Nantes Univ Hosp, Hematol Dept, Nantes, France
[2] Univ Nantes, CRCINA IRS UN, INSERM, UMR1232, Nantes, France
[3] Nantes Univ Hosp, Hematol Biol Dept, Nantes, France
关键词
COVID-19; allogeneic; vaccine; infection; BNT162b2; mRNA-1273;
D O I
10.1080/21645515.2024.2370970
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The impact of pre-graft COVID-19 vaccinations in donor or recipient as well as pre-graft infection has been studied in 157 adults having received allogeneic stem cell transplantation (Allo-SCT) for various hematological diseases during the delta/omicron waves. We showed here that pre-Allo-SCT COVID-19 vaccination and/or infection do not provide more protection in patients receiving vaccine, immunotherapy or both after transplant. COVID-19 vaccination is and remains of crucial importance after Allo-SCT, reinforcing the recommendation to start COVID-19 vaccination as soon as the third month following the transplant.
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页数:5
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