Significance of PD-L1 and Tumor Microenvironment in Laryngeal Squamous Cell Cancer

被引:0
|
作者
Tudor, Filip [1 ,2 ]
Marijic, Blazen [1 ,2 ]
Babarovic, Emina [2 ,3 ]
Hadzisejdic, Ita [2 ,3 ]
机构
[1] Clin Hosp Ctr Rijeka, Dept Otorhinolaryngol Head & Neck Surg, Rijeka 51000, Croatia
[2] Univ Rijeka, Fac Med, Rijeka 51000, Croatia
[3] Clin Hosp Ctr Rijeka, Clin Dept Pathol & Cytol, Rijeka, Croatia
关键词
laryngeal carcinoma; PD-L1; tumor microenvironment; survival; INFILTRATING LYMPHOCYTES; STANDARDIZED METHOD; SOLID TUMORS; CARCINOMA; NECK; HEAD; PATHOLOGISTS; EXPRESSION; PROGNOSIS; PROPOSAL;
D O I
10.3390/cancers16152645
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Despite the considerable advancement in the field of medicine over recent decades, laryngeal cancer continues to be a challenge. The field of immune oncology has generated promising immunomodulation therapies and opened up new ways of treatment. Methods: Our retrospective study included 102 patients diagnosed with laryngeal squamous cell cancer (LSCC). Immunohistochemistry was used to evaluate the expression of PD-L1 and tumor microenvironment cells (CD4, CD8, CD68 and CD163). Results: PD-L1 expression showed statistically significant positive correlations with all examined tumor microenvironment cells. Patients with high CD68 and CD163 expression intratumorally (p = 0.0005 and p = 0.006, respectively) had statistically significant shorter disease-specific survival. Moreover, a statistically shorter time to recurrence was found in patients with high CD68 intratumoral and CD8 overall counts (p = 0.049 and p = 0.019, respectively). Also, high CD8 overall (>23%) and CD68 intratumoral (>2.7%) expression were statistically significant predictors of recurrence (p = 0.028, OR = 3.11 and p = 0.019, OR = 3.13, respectively). Conclusions: Higher CD68 and CD163 expression represented significantly worse prognosticators for clinical outcomes in patients with LSCC. In order to determine which LSCC patients will benefit from anti-PD-1/PD-L1 inhibitors, it is crucial to elucidate the relationship between PD-L1 expression, immune cell distribution and prognosis in LSCC patients.
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页数:20
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