Tumour microenvironment-responded Fe-doped carbon dots-sensitized cubic Cu2O for Z-scheme heterojunction-enhanced sono-chemodynamic synergistic tumor therapy

被引：10

作者：

Feng, Chuanqi ^{[1
]}

Wang, Lumin ^{[1
]}

Zhang, Dashuai ^{[1
]}

Geng, Longlong ^{[1
]}

Zhou, Lianwen ^{[1
]}

Wang, Ling ^{[1
]}

Tian, Guanfeng ^{[1
]}

Tang, Qi ^{[1
]}

Hu, Jinyan ^{[2
]}

Geng, Bijiang ^{[2
]}

Yan, Lang ^{[3
]}

机构：

[1] Dezhou Univ, Coll Chem & Chem Engn, Shandong Prov Key Lab Monocrystalline Silicon Semi, Dezhou 253023, Shandong, Peoples R China

[2] Shanghai Univ, Sch Environm & Chem Engn, Shanghai 200444, Peoples R China

[3] Naval Med Univ, Fac Naval Med, Dept Hlth Toxicol, Shanghai 200433, Peoples R China

来源：

JOURNAL OF COLLOID AND INTERFACE SCIENCE | 2024年 / 665卷

关键词：

Fe-CDs; Cu2O; Z-scheme heterojunctions; Sonodynamic therapy; Chemodynamic therapy; NANOCUBES;

D O I：

10.1016/j.jcis.2024.03.175

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The efficacy of electron -hole separation in a single sonosensitizer and the complexities of the tumor microenvironment (TME) present significant challenges to the effectiveness of sonodynamic therapy (SDT). Designing efficient sonosensitizers to enhance electron -hole separation and alleviate TME resistance is crucial yet challenging. Herein, we introduce a novel Z -scheme heterojunctions (HJs) sonosensitizer using Fe -doped carbon dots (CDs) as auxiliary semiconductors to sensitize cubic Cu 2 O (Fe-CDs@Cu 2 O) for the first time. Fe-CDs@Cu 2 O demonstrated enhanced SDT effects due to improved electron -hole separation. Additionally, the introduction of Fe ions in CDs synergistically enhances Fenton -like reactions with Cu ions in Cu 2 O, resulting in enhanced chemodynamic therapy (CDT) effects. Moreover, Fe-CDs@Cu 2 O exhibited rapid glutathione (GSH) depletion, effectively mitigating TME resistance. With high rates of 1 O 2 and center dot OH generated by Fe-CDs@Cu 2 O, coupled with

引用

页码：681 / 692

页数：12