Antioxidant and anti-Alzheimer's disease activities of 1,8-cineole and its cyclodextrin inclusion complex

被引：4
|
作者：
Tan, Xin [1 ,2 ]
Xu, Rui [1 ,2 ]
Li, Ai -Pei [5 ]
Li, Dan [1 ,2 ]
Wang, Yun [1 ,2 ]
Zhao, Qian [1 ,2 ]
Long, Li-Ping [1 ,2 ]
Fan, Yu-Zhou [1 ,2 ]
Zhao, Chen-Xiao [1 ,2 ]
Liu, Yan [1 ,2 ]
Li, Sheng-Hong [1 ,2 ,3 ,4 ]
机构：
[1] Chengdu Univ Tradit Chinese Med, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China
[2] Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Chengdu 611137, Peoples R China
[3] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochemistry & Plant Resources Wes, Kunming 650201, Peoples R China
[4] Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Peoples R China
[5] Chengdu Univ Tradit Chinese Med, Coll Med Technol, Chengdu 611137, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2024年 / 175卷
关键词：
8-Cineole; Antioxidant activity; Anti-Alzheimer's disease activity; Anti-Afl aggregation activity; Cyclodextrin inclusion complex; Caenorhabditis elegans; 1;
D O I：
10.1016/j.biopha.2024.116784
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
1,8-Cineole is a bicyclic monoterpene widely distributed in the essential oils of various medicinal plants, and it exhibits significant anti-inflammatory and antioxidant activities. We aimed to investigate the therapeutic effect of 1,8-cineole on anti-Alzheimer's disease by using transgenic Caenorhabditis elegans models. Our studies demonstrated that 1,8-cineole significantly relieved Afl1-42-induced paralysis and exhibited remarkable antioxidant and anti-Afl1-42 aggregation activities in transgenic nematodes CL4176, CL2006 and CL2355. We developed a 1,8-cineole/cyclodextrin inclusion complex, displaying enhanced anti-paralysis, anti-Afl aggregation and antioxidant activities compared to 1,8-cineole. In addition, we found 1,8-cineole treatment activated the SKN-1/ Nrf-2 pathway and induced autophagy in nematodes. Our results demonstrated the antioxidant and anti-Alzheimer's disease activities of 1,8-cineole, which provide a potential therapeutic approach for Alzheimer's disease.
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页数：11
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