Current Progress and Future Perspectives in Contact and Releasing-Type Antimicrobial Coatings of Orthopaedic Implants: A Systematic Review Analysis Emanated from In Vitro and In Vivo Models

被引：0

作者：

Kaspiris, Angelos ^{[1
]}

Vasiliadis, Elias ^{[1
]}

Pantazaka, Evangelia ^{[2
]}

Lianou, Ioanna ^{[3
,4
]}

Melissaridou, Dimitra ^{[5
]}

Savvidis, Matthaios ^{[6
]}

Panagopoulos, Fotios ^{[3
,4
]}

Tsalimas, Georgios ^{[1
]}

Vavourakis, Michail ^{[1
]}

Kolovos, Ioannis ^{[1
]}

Savvidou, Olga D. ^{[5
]}

Pneumaticos, Spiros G. ^{[1
]}

机构：

[1] Natl & Kapodistrian Univ Athens, KAT Gen Hosp, Sch Med, Dept Orthopaed Surg 3, Nikis 2, Athens 14561, Greece

[2] Univ Patras, Dept Chem, Synthet Organ Chem Lab, Patras 26504, Greece

[3] Univ Patras, Rion Univ Hosp, Dept Orthopaed Surg, Patras 26504, Greece

[4] Univ Patras, Med Sch, Sch Hlth Sci, Patras 26504, Greece

[5] Natl & Kapodistrian Univ Athens, ATTIKON Univ Hosp, Sch Med, Dept Orthopaed Surg 1, Rimini 1, Athens 12462, Greece

[6] 424 Gen Mil Hosp, Orthoped Dept 2, Thessaloniki 56429, Greece

来源：

INFECTIOUS DISEASE REPORTS | 2024年 / 16卷 / 02期

关键词：

preclinical studies; orthopedic implants; antimicrobial coatings; biocompatibility; osseointegration; RESISTANT STAPHYLOCOCCUS-AUREUS; TITANIUM IMPLANTS; ANTIBACTERIAL ACTIVITY; LINEZOLID PENETRATION; BONE; INFECTION; SILVER; HYDROXYAPATITE; OSSEOINTEGRATION; EFFICACY;

D O I：

10.3390/idr16020025

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Background: Despite the expanding use of orthopedic devices and the application of strict pre- and postoperative protocols, the elimination of postoperative implant-related infections remains a challenge. Objectives: To identify and assess the in vitro and in vivo properties of antimicrobial-, silver- and iodine-based implants, as well as to present novel approaches to surface modifications of orthopedic implants. Methods: A systematic computer-based review on the development of these implants, on PubMed and Web of Science databases, was carried out according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Results: Overall, 31 in vitro and 40 in vivo entries were evaluated. Regarding the in vitro studies, antimicrobial-based coatings were assessed in 12 entries, silver-based coatings in 10, iodine-based in 1, and novel-applied coating technologies in 8 entries. Regarding the in vivo studies, antimicrobial coatings were evaluated in 23 entries, silver-coated implants in 12, and iodine-coated in 1 entry, respectively. The application of novel coatings was studied in the rest of the cases (4). Antimicrobial efficacy was examined using different bacterial strains, and osseointegration ability and biocompatibility were examined in eukaryotic cells and different animal models, including rats, rabbits, and sheep. Conclusions: Assessment of both in vivo and in vitro studies revealed a wide antimicrobial spectrum of the coated implants, related to reduced bacterial growth, inhibition of biofilm formation, and unaffected or enhanced osseointegration, emphasizing the importance of the application of surface modification techniques as an alternative for the treatment of orthopedic implant infections in the clinical settings.

引用

页码：298 / 316

页数：19