Procalcitonin in inflammatory bowel disease: A diagnostic or prognostic marker

被引：1
|
作者：
Pournaghi, Seyed-Javad [1 ]
Jamialahmadi, Hamid [2 ]
Pazhohan-Nezhad, Hadis [3 ]
Moghbeli, Meysam [2 ]
Saburi, Amin [4 ]
Eghbal, Fatemeh [5 ]
Nakhlband, Ailar [5 ]
Saburi, Ehsan [2 ,6 ,7 ]
机构：
[1] North Khorasan Univ Med Sci, Sch Med, Dept Gastroenterol & Liver Dis, Bojnurd, Iran
[2] Mashhad Univ Med Sci, Sch Med, Dept Med Genet & Mol Med, Mashhad, Iran
[3] Islamic Azad Univ, Dept Biol, Mashhad Branch, Mashhad, Iran
[4] Afarinesh Nasle Mana Clin, Mashhad, Iran
[5] Next Generat Genet Polyclin, Dept Med Genet, Mashhad, Iran
[6] Tabriz Univ Med Sci, Biomed Inst, Res Ctr Pharmaceut Nanotechnol, Tabriz, Iran
[7] Mashhad Univ Med Sci, Med Genet Res Ctr, Mashhad, Iran
来源：
PATHOLOGY RESEARCH AND PRACTICE | 2024年 / 262卷
关键词：
Inflammatory bowel disease; Serological biomarkers; Procalcitonin; Disease activity; C-REACTIVE PROTEIN; SERUM PROCALCITONIN; INFECTED NECROSIS; EARLY PREDICTION; ACUTE REJECTION; CROHNS-DISEASE; EPIDEMIOLOGY; CHILDREN; MANAGEMENT; EFFICACY;
D O I：
10.1016/j.prp.2024.155548
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Serological biomarkers have been rapidly progressing as non-invasive tests for the early detection of inflammatory bowel disease (IBD). Procalcitonin (PCT) is a novel acute-phase reactant protein that is elevated in the inflammatory process, especially in bacterial infections. This study aimed to review the diagnostic value of PCT in IBD activity. However, there were controversies about the role of PCT in the detecting of IBD disease activity. Studies showed varied diagnostic cut-points (ranging from 0.13 to 1.0 ng/dl) and sensitivity up to 93%. Although the clear role of PCT as a valuable diagnostic marker was not identified in determining disease activity, PCT measurement in addition to other inflammatory markers can improve the diagnostic value of these markers. Moreover, further studies are required to confirm PCT's value in distinguishing IBD disease activity.
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页数：6
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