Site Effects in Multisite Fetal Brain MRI: A Morphological Study of Early Brain Development

被引:1
|
作者
Xu, Xinyi [1 ]
Xu, Haoan [1 ]
Zheng, Tianshu [1 ]
Wang, Yutian [1 ]
Zhou, Chi [1 ]
Xiao, Jiaxin [1 ,2 ]
Chen, Ruike [1 ]
Li, Mingyang [1 ]
Sun, Cong [3 ]
Kong, Xianglei [4 ]
Zhu, Qingqing [4 ]
Yu, Hong [5 ]
Yan, Guohui [6 ]
Zou, Yu [6 ]
Wang, Jingshi [5 ]
Wang, Guangbin [7 ]
Wu, Dan [1 ]
机构
[1] Zhejiang Univ, Dept Biomed Engn, Coll Biomed Engn & Instrument Sci, 38 Zheda Rd, Hangzhou, Peoples R China
[2] Kings Coll London, Sch Biomed Engn & Imaging Sci, Fac Life Sci & Med, London, England
[3] Chinese Acad Med Sci, Beijing Hosp, Inst Geriatr Med, Natl Ctr Gerontol,Dept Radiol, Beijing, Peoples R China
[4] Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Radiol, Sch Med, Hangzhou, Peoples R China
[5] Dalian Municipal Women & Childrens Med Ctr Grp, Dalian, Peoples R China
[6] Zhejiang Univ, Womens Hosp, Dept Radiol, Sch Med, Hangzhou, Peoples R China
[7] Shandong First Med Univ, Shandong Prov Hosp, Dept Radiol, Jinan, Shandong, Peoples R China
关键词
Multisite; Fetal brain; Morphological development; Harmonization; Cortical thickness; CORTICAL DEVELOPMENT; THICKNESS; PATTERNS; SCANNER;
D O I
10.1007/978-3-031-51455-5_16
中图分类号
TP18 [人工智能理论];
学科分类号
081104 ; 0812 ; 0835 ; 1405 ;
摘要
Studies have shown that the non-biological site-related effects may induce bias in multisite neuroimaging studies among adults and adolescents. It is unknown how site effects would affect fetal brain MRI and which acquisition factors are critical in quantitative analysis. In this study, we identified site effects, including manufacture, field strength, in-plane resolution, and slice thickness on structural subcortical volume and cortical thickness measurements in normal fetuses. We also showed these site effects could be effectively removed with ComBat-GAM while preserving developmental patterns indicating that the harmonization procedure is necessary when combing multisite imaging data to study fetal brain morphological development.
引用
收藏
页码:131 / 139
页数:9
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