Efficacy of Minocycline Hydrochloride Ointment with Metronidazole in the Treatment of Chronic Periodontitis and its Impact on Periodontal Microecology

Examining the efficacy of the combined application of minocycline hydrochloride ointment and metronidazole for treating chronic periodontitis and studying its impact on periodontal microecology. The research involved dividing 235 chronic periodontitis patients into an observation group and a control group for further analysis. Both sets of participants underwent fundamental periodontal therapy, with the control cohort undergoing metronidazole treatment, and the observation cohort undergoing combined minocycline hydrochloride ointment and metronidazole treatment. A month into the treatment, the treatment effectiveness was appraised, and an evaluation of the periodontal indices, such as the gingival index, plaque index and probing depth, was carried out. Collection of gingival crevicular fluid samples for assessment of inflammatory factors and immune cell levels was conducted, alongside the documentation of bacterial colony counts in the periodontal microecology. The overall effectiveness rate in the observation group stood at 96.00 %, a significant increase compared to the 84.00 % noted in the control group. Decreases in the gingival index, plaque index and probing depth indices were observed in the observation group, and these reductions were greater than those in the control group. Furthermore, the reduction in inflammatory factor levels in the gingival crevicular fluid was more notable in the observation group than in the control group. Greater declines in the levels of T(h)17 and T-reg cells were observed in the observation group relative to the control group. Additionally, the observation group saw a reduction in the bacterial colony count of harmful bacteria in periodontal microecology, paired with an increase in beneficial bacteria. The use of minocycline hydrochloride ointment in conjunction with metronidazole in chronic periodontitis patients leads to a notable improvement in periodontal indices, a reduction in inflammatory responses, the modulation of T(h)17 and T-reg cell levels, and the preservation of periodontal microecology.