The Basic Requirement of Tight Junction Proteins in Blood-Brain Barrier Function and Their Role in Pathologies

被引：2
|
作者：
Dithmer, Sophie [1 ]
Blasig, Ingolf E. [1 ]
Fraser, Paul A. [2 ]
Qin, Zhihai [3 ]
Haseloff, Reiner F. [1 ]
机构：
[1] Leibniz Forschungsinst Mol Pharmakol, Robert-Rossle-Str 10, D-13125 Berlin, Germany
[2] Kings Coll London, London WC2R 2LS, England
[3] Chinese Acad Sci, Inst Biophys, Beijing 100049, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 11期
关键词：
tight junction proteins; blood-brain barrier; tight junction structure; cerebral disease; claudins; occludin; MESSENGER-RNA EXPRESSION; CAPILLARY ENDOTHELIAL-CELLS; COILED-COIL-DOMAIN; ZONULA OCCLUDENS-1 AND-2; SMALL VESSEL DISEASE; 2ND PDZ DOMAIN; ADHESION-MOLECULE; EPITHELIAL BARRIER; ADHERENS JUNCTIONS; IN-VITRO;
D O I：
10.3390/ijms25115601
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This review addresses the role of tight junction proteins at the blood-brain barrier (BBB). Their expression is described, and their role in physiological and pathological processes at the BBB is discussed. Based on this, new approaches are depicted for paracellular drug delivery and diagnostics in the treatment of cerebral diseases. Recent data provide convincing evidence that, in addition to its impairment in the course of diseases, the BBB could be involved in the aetiology of CNS disorders. Further progress will be expected based on new insights in tight junction protein structure and in their involvement in signalling pathways.
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页数：36
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