Aging and neurodegeneration: From molecular mechanisms to therapeutic interventions

被引：1

作者：

Outeiro, Tiago Fleming ^{[1
,2
,3
,4
]}

Brocardo, Patricia S. ^{[5
]}

Gelain, Daniel P. ^{[6
]}

机构：

[1] Univ Med Ctr Gottingen, Ctr Biostruct Imaging Neurodegenerat, Dept Expt Neurodegenerat, Gottingen, Germany

[2] Max Planck Inst Multidisciplinary Sci, Gottingen, Germany

[3] Newcastle Univ, Translat & Clin Res Inst, Fac Med Sci, Framlington Pl, Newcastle Upon Tyne, England

[4] Deutsch Zentrum Neurodegenerat Erkrankungen DZNE, Gottingen, Germany

[5] Univ Fed Santa Catarina, Dept Morphol Sci, Neurosci Grad Program, Florianopolis, Brazil

[6] Univ Fed Rio Grande do Sul, Inst Basic Hlth Sci, Dept Biochem, Porto Alegre, Brazil

来源：

JOURNAL OF NEUROCHEMISTRY | 2024年 / 168卷 / 08期

关键词：

aging; neurodegeneration; neuronal plasticity; protein aggregation; therapeutics;

D O I：

10.1111/jnc.16163

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein aggregation is a common age-associated process and can be a pathological hallmark of various neurodegenerative conditions, possibly because of an age-associated decline in the activity of components of the proteostasis network. The specific molecular drivers of protein aggregation in certain cell types are not well understood, posing tremendous challenges to current research aimed at devising strategies to treat neurodegenerative diseases. This preface introduces the special issue "Aging and Neurodegeneration: from molecular mechanisms to therapeutic interventions," featuring articles that assess the drivers of pathology in the aging cell, including oxidative stress, protein glycation/aggregation, and mitochondrial impairment.

引用

页码：1423 / 1425

页数：3

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