Assessing antibacterial efficacy of a polyhexanide hydrogel versus alginate-based wound dressing in burns

被引:0
|
作者
De Decker, Ignace [1 ,2 ]
Janssens, Dries [3 ]
De Mey, Kimberly [1 ]
Hoeksem, Henk [1 ,2 ]
Simaey, Marie [1 ]
De Coninck, Petra [1 ]
Verbelen, Jozef [1 ]
De Pessemier, Alina [3 ]
Blondeel, Phillip [1 ,2 ]
Monstrey, Stan [1 ,2 ]
Claes, Karel E. Y. [1 ,2 ]
机构
[1] Ghent Univ Hosp, Burn Ctr, C Heymanslaan 10, B-9000 Ghent, Belgium
[2] Ghent Univ Hosp, Dept Plast Surg, C Heymanslaan 10, B-9000 Ghent, Belgium
[3] Univ Ghent, Fac Med & Hlth Sci, C Heymanslaan 10, B-9000 Ghent, Belgium
关键词
alginate; betaine; burn; laser Doppler imaging; polyhexanide; Pseudomonas aeruginosa; Staphylococcus aureus; wound; wound care; wound dressing; wound healing; ENZYMATIC DEBRIDEMENT NEXOBRID(R); STAPHYLOCOCCUS-AUREUS INFECTIONS; SILVER SULFADIAZINE; EXTRACELLULAR DNA; ESCHAR REMOVAL; CARE; EPIDEMIOLOGY; MANAGEMENT; ALGINOGEL; BIOFILMS;
D O I
暂无
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Objective: Burn injuries pose a heightened risk of infection, which is primarily responsible for increased morbidity and mortality. Factors such as extensive skin damage and compromised immunity exacerbate this vulnerability. Pseudomonas aeruginosa and Staphylococcus aureus are frequently identified in burns, with Gram -negative Pseudomonas aeruginosa often resistant to antibacterial agents. While Flaminal, an alginate-based wound dressing (Flen Health, Belgium), aids wound healing, its antibacterial effects are limited compared with 1% silver sulfadiazine (1% SSD). In contrast, Prontosan Wound Gel X, a betaine and polyhexanide-based hydrogel (B. Braun Medical AG, Switzerland), has been shown to effectively combat various microbes and promotes wound healing.<br /> Method: In this study, two research cohorts were retrospectively established (control group: patients receiving standard of care with the alginate-based wound dressing; intervention group: patients receiving the polyhexanide hydrogel wound dressing), comprising patients admitted to a burn centre between 2019 and 2022. Patients were eligible when continuous wound treatment with either of the two wound dressings was performed. Laser Doppler imaging (LDI) scans were conducted. Regions of interest (ROIs) were selected based on LDI scans and divided into healing time categories. Wound swabs were collected and the presence of Pseudomonas aeruginosa and Staphylococcus aureus was documented. Bacterial load was evaluated using a semiquantitative scale. Wound healing was recorded. Results: The control group consisted of 31 patients with 93 ROIs, while the intervention group had 67 ROIs involving 29 patients. Both groups exhibited similar proportions of healing time categories (p>0.05). The polyhexanide hydrogel dressing outperformed the alginate-based dressing in antiseptic efficacy by significantly reducing the incidence of Pseudomonas aeruginosa - and Staphylococcus aureus -positive cultures in patients' wounds. Wound healing time for conservative treatment was comparable between groups. Conclusion: In this study, the polyhexanide hydrogel dressing minimised Pseudomonas aeruginosa and Staphylococcus aureus colonisation in burn wounds, demonstrating strong antibacterial properties, emphasising its potential to minimise infections in burn injuries.
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页数:12
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