Therapeutic effects of Tanshinone IIA and Tetramethylpyrazine nanoemulsions on cognitive impairment and neuronal damage in Alzheimer's disease rat models

被引：0
|
作者：
Fang, Liang [1 ,2 ,3 ,4 ,5 ]
Cheng, Hongyan [1 ,2 ,3 ,4 ,5 ]
Chen, Weidong [1 ,2 ,3 ,4 ,5 ]
Peng, Can [1 ,2 ,3 ,4 ,5 ]
Liu, Yuanxu [1 ,2 ,3 ,4 ,5 ]
Zhang, Caiyun [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Anhui Univ Chinese Med, Sch Pharm, Anhui Prov Key Lab Pharmaceut Preparat Technol & A, Hefei 230012, Anhui, Peoples R China
[2] Anhui Educ Dept AUCM, Engn Technol Res Ctr Modernized Pharmaceut, Hefei 230012, Anhui, Peoples R China
[3] Anhui Univ Chinese Med, Inst Pharmacokinet, Hefei 230012, Anhui, Peoples R China
[4] Anhui Genuine Chinese Med Mat Qual Improvement Col, Hefei 230012, Anhui, Peoples R China
[5] Anhui Univ Chinese Med, Anhui Acad Chinese Med, Hefei 230012, Peoples R China
来源：
JOURNAL OF PHARMACY AND PHARMACOLOGY | 2024年 / 76卷 / 09期
关键词：
brain-targeted nanodrug delivery system; Alzheimer's disease; oxidative stress injury; neuronal apoptosis; MAPK/ERK/CREB signaling pathway; OXIDATIVE STRESS; NEUROINFLAMMATION; DYSFUNCTION; PROTECTS; DEFICITS; PATHWAY; TRANS;
D O I：
10.1093/jpp/rgae069
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Objectives The aim of this study was to investigate the therapeutic effects and related mechanisms of Tanshinone IIA and Tetramethylpyrazine O/W composite nanoemulsions on Alzheimer's disease (AD) rats.Methods The therapeutic effect of TSN/TMP O/W NEs on AD rats was evaluated by behavioral tests, H&E, Nissl, and Immunohistochemistry staining. ELISA and Western blot were used to analyze the mechanism.Key findings The results showed that TSN/TMP O/W NEs could down-regulate the expression of Bax and Caspase-3 proteins, decrease the level of MDA, increase the expression of SOD and GSH-Px, and alleviate cognitive impairment in AD rats.Conclusions TSN/TMP O/W NEs can inhibit MAPK/ERK/CREB signaling pathway and effectively alleviate cognitive impairment, oxidative stress injury, and neuronal apoptosis in AD rats.
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页码：1169 / 1177
页数：9
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