Antifungal resistance: why are we losing this battle?

被引：0
|
作者：
Macedo, Jamile de Paiva [1 ]
Dias, Vanessa Cordeiro [2 ]
机构：
[1] Fed Univ Juiz De Fora UFJF, Biol?Sci, Rua Jose Lourenco Kelmer,S-N,Sao Pedro, BR-36036900 Juiz De Fora, MG, Brazil
[2] Fed Univ Juiz De Fora UFJF, Dept Parasitol Microbiol & Immunol, Rua Jose Lourenco Kelmer,S-N,Sao Pedro, BR-36036900 Juiz De Fora, MG, Brazil
来源：
FUTURE MICROBIOLOGY | 2024年 / 19卷 / 11期
关键词：
amphotericin B; antifungal agents; antifungal resistance; azole; biofilm; echinocandin; CANDIDA-ALBICANS; AMPHOTERICIN-B; ECHINOCANDIN RESISTANCE; ASPERGILLUS-FUMIGATUS; SUSCEPTIBILITY; BIOFILM; EPIDEMIOLOGY; PROTEINASES; MECHANISMS; TROPICALIS;
D O I：
10.1080/17460913.2024.2342150
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The emergence of fungal pathogens and changes in the epidemiological landscape are prevalent issues in clinical mycology. Reports of resistance to antifungals have been reported. This review aims to evaluate molecular and nonmolecular mechanisms related to antifungal resistance. Mutations in the ERG genes and overexpression of the efflux pump (MDR1, CDR1 and CDR2 genes) were the most reported molecular mechanisms of resistance in clinical isolates, mainly related to Azoles. For echinocandins, a molecular mechanism described was mutation in the FSK genes. Furthermore, nonmolecular virulence factors contributed to therapeutic failure, such as biofilm formation and selective pressure due to previous exposure to antifungals. Thus, there are many public health challenges in treating fungal infections.
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页码：1027 / 1040
页数：14
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