Metabolic regulation of preimplantation embryo development in vivo and in vitro: Molecular mechanisms and insights

被引：4
|
作者：
Lee, Seok Hee [1 ]
Rinaudo, Paolo F. [1 ]
机构：
[1] Univ Calif San Francisco, Ctr Reprod Sci, Dept Obstet & Gynecol, San Francisco, CA 94143 USA
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2024年 / 726卷
基金：
新加坡国家研究基金会;
关键词：
Embryo development; Metabolism; Assisted reproductive technologies; Metabolic disorders; Metabolic pathway; NOTCH SIGNALING PATHWAY; JAK-STAT PATHWAY; INNER CELL MASS; BOVINE EMBRYOS; GENE-EXPRESSION; MOUSE EMBRYOS; AMINO-ACIDS; OXIDATIVE-PHOSPHORYLATION; OXYGEN CONCENTRATION; GLUCOSE-METABOLISM;
D O I：
10.1016/j.bbrc.2024.150256
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Understanding of embryonic development has led to the clinical application of Assisted Reproductive technologies (ART), with the resulting birth of millions of children. Recent developments in metabolomics, proteomics, and transcriptomics have brought to light new insights into embryonic growth dynamics, with implications spanning reproductive medicine, stem cell research, and regenerative medicine. The review explores the key metabolic processes and molecular pathways active during preimplantation embryo development, including PI3K-Akt, mTOR, AMPK, Wnt/beta-catenin, TGF-beta, Notch and Jak-Stat signaling pathways. We focused on analyzing the differences occurring in vitro as opposed to in vivo development and we discussed significant physiological and clinical implications.
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页数：10
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