Micronutrient Status and Breast Cancer: A Narrative Review

被引:5
|
作者
Forma, Alicja [1 ]
Grunwald, Arkadiusz [1 ]
Zembala, Patryk [2 ]
Januszewski, Jacek [3 ]
Brachet, Adam [1 ]
Zembala, Roksana [4 ]
Swiatek, Kamila [3 ]
Baj, Jacek [3 ]
机构
[1] Med Univ Lublin, Chair & Dept Forens Med, Jaczewskiego 8b, PL-20090 Lublin, Poland
[2] Med Univ Warsaw, Fac Med, Banacha 1A, PL-02097 Warsaw, Poland
[3] Med Univ Lublin, Chair Fundamental Sci, Dept Correct Clin & Imaging Anat, Jaczewskiego 4, PL-20090 Lublin, Poland
[4] Cardinal Stefan Wyszynski Univ Warsaw, Fac Med, Woycickiego 1-3, PL-01938 Warsaw, Poland
关键词
micronutrients; breast cancer; vitamins; metallomics; nutritional status; nutrition; trace element; TRANS-RETINOIC ACID; VITAMIN-D SUPPLEMENTATION; ONE-CARBON METABOLISM; DOUBLE-EDGED-SWORD; OXIDATIVE STRESS; CELL-DEATH; ZINC DYSREGULATION; DIETARY-INTAKE; TUMOR-GROWTH; DNA-DAMAGE;
D O I
10.3390/ijms25094968
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Breast cancer is one of the most common cancers worldwide, at the same time being one of the most prevalent causes of women's death. Many factors such as alcohol, weight fluctuations, or hormonal replacement therapy can potentially contribute to breast cancer development and progression. Another important factor in breast cancer onset includes micronutrient status. In this narrative review, we analyzed 23 micronutrients and their possible influence on breast cancer onset and progression. Further, the aim of this study was to investigate the impact of micronutrient status on the prevention of breast cancer and its possible influence on various therapeutic pathways. We researched meta-analyses, systemic and narrative reviews, retrospective studies, as well as original studies on human and animal models. The results of these studies indicate a possible correlation between the different levels of micronutrients and a decreased risk of breast cancer as well as a better survival rate. However, further studies are necessary to establish adequate doses of supplementation of the chosen micronutrients and the exact mechanisms of micronutrient impact on breast cancer therapy.
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页数:36
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