Evaluating the Leishmania tarentolae response to inorganic strontium-based oxyfluorides

被引：0
|
作者：
Terry, Katelyn [1 ]
Drinkwater, Joseph [2 ]
Jones, Marjorie A. [1 ]
Sullivan, Eirin [2 ]
机构：
[1] Illinois State Univ, Dept Chem, Normal, IL USA
[2] Univ North Florida, Jacksonville, FL 32224 USA
来源：
HELIYON | 2024年 / 10卷 / 09期
关键词：
Leishmania; Leishmaniasis; Anti-perovskites; Strontium; Calcium; Gallium; Oxyfluorides; Secreted acid phosphatases; Leishmania secreted proteases; ANTI-PEROVSKITES; BA;
D O I：
10.1016/j.heliyon.2024.e30634
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The increasing global prevalence of the parasitic vector-borne disease leishmaniasis combined with rising resistance to current therapeutics necessitates the search for novel approaches to combat leishmania. This study evaluates the effects of novel strontium-based oxyfluorides for potential therapeutic use by testing cultures of Leishmania tarentolae, , a species of Leishmania found in reptiles, as a model species. Cells were cultured with a range of mixed metal strontium oxyfluoride compounds selected to systematically test the relationship between compound structure and cell viability and enzyme activity over time.
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页数：7
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