High-avidity BCMA CAR and high- affinity, non-cleavable CD16 Fc receptor incorporated in off-the-shelf CAR T cells promote multi-antigen targeting and durable anti-tumor cytotoxicity in the treatment of multiple myeloma

被引:0
|
作者
Reiser, John
O'Connor, Alison
Hancock, Bryan
Markov, Spas
Groff, Brian
Gutierrez, Alma
Meza, Miguel
Jelcik, Mark
Pan, Yijia
Garcia, Alex
Goulding, Bobby
Denholtz, Matthew
Lee, Tom
Abujarour, Ramzey
Bjordahl, Ryan
Rehm, Armin
Clarke, Raedun
Goodridge, Jode
Valamehr, Bahram
机构
关键词
D O I
10.1158/1538-7445.AM2024-3618
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
3618
引用
收藏
页数:2
相关论文
共 1 条
  • [1] Multiplexed Engineered, Off-the-Shelf T Cells Carrying Three Tumor-Associated Antigen-Targeting Modalities: CAR plus Pan-Tumor Targeting TCR+CD16 Fc Receptor
    Nguyen, Cokey
    Peralta, Eigen
    Chang, Chia-Wei
    Yeh, Wen-I
    Pan, Yijia
    Lu, Dan
    Sumi, May
    Pribadi, Mochtar
    Yang, Bi-Huei
    Sung, Eric
    Witty, Alec
    Lee, Tom
    BLOOD, 2020, 136