Field studies were conducted to assess the efficacy of pyroxasulfone alone and its combinations with other herbicides at different time of application against a diverse weed flora in wheat ( Triticum aestivum L). Applications of pyroxasulfone at 125 g/ha as pre-emergence (PE) or early post-emergence (EPO) at 20 days after sowing effectively controlled the grass weeds ( Phalaris minor Retz. and Avena ludoviciana Durieu). However, pyroxasulfone alone exhibited poor control of broad-leaved weeds, such as Medicago denticulata Willd and Rumex dentatus L. To address the limitations in controlling broad-leaved weeds, tank mix combinations of pyroxasulfone at 125 g/ha with either pendimethalin at 1000 g/ha or metsulfuron at 4 g/ha or metribuzin at 300 g/ha proved highly effective. Pre-emergence pyroxasulfone application in combination with either metsulfuron (125 + 4 g/ ha) or with metribuzin (125 + 300 g/ha) in wheat gave effective control of diverse weed flora and improved wheat productivity by 52.1% and 51.2%, respectively, over untreated control. Ready mix combination of clodinafop + metribuzin 60 + 210 g/ha applied as post emergence (32 DAS) provided >99% control of P. minor, A . ludoviciana, , M . denticulata and R . dentatus L., however the phytotoxicity with this treatment produced 6.7% lower yield as compared to season long weed free conditions. Among the herbicidal treatments, pre-emergence application of pyroxasulfone + metsulfuron at 125 + 4 g/ha had the highest net returns followed by alone application of pre-emergence metribuzin at 300 g/ha.