Recent Advances in the Synthesis of Diarylheptanoids

被引：0

作者：

Sudarshan, Kasireddy ^{[1
]}

Yarlagadda, Suresh ^{[1
]}

Sengupta, Sagnik ^{[1
]}

机构：

[1] Purdue Univ, Inst Drug Discovery, Dept Chem, W Lafayette, IN 47907 USA

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2024年 / 19卷 / 15期

关键词：

Curcumin; Centrolobine; Diarylheptanoids; Olefin metathesis; Macrocyclization; STEREOSELECTIVE TOTAL-SYNTHESIS; 4-ARYLIDENE CURCUMIN ANALOGS; ASYMMETRIC TOTAL SYNTHESES; ALNUS-HIRSUTA INHIBIT; OXA-MICHAEL REACTION; 1ST TOTAL-SYNTHESIS; NATURAL-PRODUCTS; ACEROGENIN-A; CYTOTOXIC DIARYLHEPTANOIDS; ENANTIOSELECTIVE SYNTHESIS;

D O I：

10.1002/asia.202400380

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In the quest for synthesizing biologically important natural products, medicinal chemists embark on an endless journey. This review focuses on the reports published towards the syntheses of diarylheptanoids, classifying them into linear, tetrahydropyran, diarylether, and biphenyl categories. The synthesis methods for each class from 2013 to 2023 are discussed, providing a comprehensive overview of the advancements in the field. Representative natural product examples are highlighted for each category. The review emphasizes the importance of diarylheptanoids in the realms of chemistry and medicine, showcasing their potential as valuable compounds for medicinal and synthetic chemists. A review covering the total syntheses of biologically significant class of diarylheptanoids during the period 2013-2023. This review covers 35 natural diarylheptanoids across linear, tetrahydropyran, diarylether and biphenyl diarylheptanoids. image

引用

页数：30

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