Topical phenytoin for wound healing: a narrative review

被引：0

作者：

Qadirifard, Mohammad S. ^{[1
,2
]}

Qadirifard, Mohammad ^{[3
]}

Tavakoli, Ghazal ^{[4
]}

Mojeni, Fariba A. ^{[5
]}

Mohagheghi, Seyede Z. ^{[6
]}

Rafiei, Seyyed K. S. ^{[7
]}

Salimi, Yasaman ^{[8
]}

Taherinik, Reza ^{[4
]}

Sheikhzadeh, Farzad ^{[4
]}

Pakrou, Neda ^{[9
]}

Poudineh, Mohadeseh ^{[10
]}

Gholami, Kosar ^{[11
]}

Dianati, Maryam ^{[12
]}

Mehrabi, Hoda ^{[13
]}

Fathi, Mobina ^{[7
]}

Deravi, Niloofar ^{[7
]}

机构：

[1] Islamic Azad Univ, Dept Nursing & Midwifery, Tehran, Iran

[2] Islamic Azad Univ, Garmsar Branch, Dept Nursing, Garmsar, Iran

[3] Shahed Univ, Fac Dent, Dept Prosthodont, Tehran, Iran

[4] Iran Univ Med Sci, Student Res Comm, Sch Med, Tehran, Iran

[5] Mazandaran Univ Med Sci, Student Res Comm, Sch Med, Sari, Iran

[6] Iran Univ Med Sci, Sch Med, Tehran, Iran

[7] Shahid Beheshti Univ Med Sci, Student Res Comm, Sch Med, Tehran, Iran

[8] Kermanshah Univ Med Sci, Student Res Comm, Kermanshah, Iran

[9] Urmia Univ Med Sci, Sch Med, Tehran, Iran

[10] Zanjan Univ Med Sci, Sch Med, Zanjan, Iran

[11] Semnan Univ Med Sci, Student Res Comm, Semnan, Iran

[12] Rafsanjan Univ Med Sci, Student Res Comm, Rafsanjan, Iran

[13] Arak Univ Med Sci, Sch Med, Student Res Comm, Arak, Iran

来源：

WOUND PRACTICE AND RESEARCH | 2024年 / 32卷 / 02期

关键词：

wound healing; phenytoin; wounds; review; SILVER SULFADIAZINE; TROPHIC ULCERS; MECHANISM; THERAPY; ZINC; METABOLISM; HYPERICIN; TISSUE; DRUGS;

D O I：

10.33235/wpr.32.2.66-78

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background In 1937, oral phenytoin medication was introduced as an anti -epileptic drug. For many years, researchers have shown interest in how topical phenytoin may be used to promote wound healing in various wounds. Purpose This review article aims to summarise and critically appraise the clinical evidence available on the effects of topical phenytoin on wound healing. Methods By using the keywords phenytoin, injuries, wound, wound care, and wound healing, we extracted articles published up to April 2022 through a search in PubMed, ISI Web of Science, SID, Google Scholar and Scopus. Result We identified 17 studies performed on human subjects and eight on rats. Phenytoin effectiveness is also compared with other wound care substances, including tretinoin, silver sulfadiazine, EUSOL, honey, dexamethasone and hypericin. Conclusion This review illustrated the significant effects and rare adverse events of topical phenytoin on wound healing.

引用

页码：66 / 78

页数：13

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