Heterogeneous Integration of Memristive and Piezoresistive MDMO-PPV-Based Copolymers in Nociceptive Transmission with Fast and Slow Pain for an Artificial Pain-Perceptual System

被引：0

作者：

Tsao, Shih-Cheng ^{[1
]}

Chang, Kuo-Hsuan ^{[2
,3
]}

Fu, Yi ^{[1
]}

Tai, Han-Hsiang ^{[1
]}

Lin, Ting-Han ^{[4
]}

Wu, Ming-Chung ^{[4
,5
,6
]}

Wang, Jer-Chyi ^{[1
,7
,8
]}

机构：

[1] Chang Gung Univ, Dept Elect Engn, Taoyuan 33302, Taiwan

[2] Chang Gung Mem Hosp, Dept Neurol, Linkou, Taoyuan 33305, Taiwan

[3] Chang Gung Univ, Coll Med, Taoyuan 33302, Taiwan

[4] Chang Gung Univ, Dept Chem & Mat Engn, Taoyuan 33302, Taiwan

[5] Chang Gung Univ, Ctr Sustainabil & Energy Technol, Taoyuan 33302, Taiwan

[6] Chang Gung Mem Hosp, Dept Pediat, Div Neonatol, Taoyuan 33305, Taiwan

[7] Chang Gung Mem Hosp, Dept Neurosurg, Taoyuan 33305, Taiwan

[8] Ming Chi Univ Technol, Dept Elect Engn, New Taipei City 243303, Taiwan

来源：

SMALL | 2024年 / 20卷 / 42期

关键词：

heterogeneous integration; memristor; nociceptive transmission; pain-perceptual system; piezoresistive pressure sensor; NEUROPATHIC PAIN; MECHANISMS; HYPERALGESIA; MONKEY; LAYER;

D O I：

10.1002/smll.202311040

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nociceptive pain perception is a remarkable capability of organisms to be aware of environmental changes and avoid injury, which can be accomplished by specialized pain receptors known as nociceptors with 4 vital properties including threshold, no adaptation, relaxation, and sensitization. Bioinspired systems designed using artificial devices are investigated to imitate the efficacy and functionality of nociceptive transmission. Here, an artificial pain-perceptual system (APPS) with a homogeneous material and heterogeneous integration is proposed to emulate the behavior of fast and slow pain in nociceptive transmission. Retention-differentiated poly[2-methoxy-5-(3,7-dimethyoctyoxyl)-1,4-phenylenevinylene] (MDMO-PPV) memristors with film thicknesses of 160 and 80 nm are manufactured and adopted as A-delta and C nerve fibers of nociceptor conduits, respectively. Additionally, a nociceptor mimic, the ruthenium nanoparticles (Ru-NPs)-doped MDMO-PPV piezoresistive pressure sensor, is fabricated with a noxiously stimulated threshold of 150 kPa. Under the application of pricking and dull noxious stimuli, the current flows predominantly through the memristor to mimic the behavior of fast and slow pain, respectively, in nociceptive transmission with postsynaptic potentiation properties, which is analogous to biological pain perception. The proposed APPS can provide potential advancements in establishing the nervous system, thus enabling the successful development of next-generation neurorobotics, neuroprosthetics, and precision medicine. Homogeneous MDMO-PPV-based copolymers with heterogeneous integration of memristive and piezoresistive properties are developed to imitate an artificial pain-perceptual system (APPS) for organisms. By integrating 2 retention-differentiated memristors and a pressure sensor, the perception of fast and slow pain in nociceptive transmission under pricking and dull noxious stimuli is realized, paving a new avenue to establish a biological nervous system. image

引用

页数：13