Ruthenium-Catalyzed Meta-Selective Trifluoroisopropylation of Arenes

被引：0

作者：

Han, Shuxiong ^{[1
]}

Liang, Min ^{[1
]}

Ju, Wenjie ^{[1
]}

Wang, Junrui ^{[1
]}

Xu, Xu ^{[1
]}

Huang, Zhibin ^{[1
]}

Zhao, Yingsheng ^{[1
,2
]}

机构：

[1] Soochow Univ, Coll Chem Chem Engn & Mat Sci Soochow, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China

[2] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453000, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 12期

关键词：

C-H ALKYLATION; TRIFLUOROMETHYLATION; FLUORINE; DIFLUOROMETHYLATION; REGIOSELECTIVITY; HETEROARENES;

D O I：

10.1021/acs.joc.4c00549

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This work reports the mild and efficient Ru-catalyzed trifluoroisopropylation of arenes using 2-bromo-1,1,1-trifluoropropane. Various bioactive molecules, such as purine and nucleoside derivatives, were well-suited for this transformation, affording the corresponding products in moderate-to-good yields. This method provides an efficient strategy for synthesizing trifluoroisopropyl molecules for drug discovery.

引用

页码：8601 / 8609

页数：9

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