Results of Single-Arm, Phase 1b Study of Anti-C1q Treatment (ANX009) Show That the Classical Pathway Is a Key Driver of Complement Activation and Consumption in Patients with Active Lupus Nephritis

被引：0

作者：

Dall'Era, Maria ^{[1
]}

Lichauco, Juan ^{[2
]}

Chen, Hsiang ^{[3
]}

Gomez, Harold ^{[4
]}

Tee, Michael ^{[5
,6
]}

Arroyo, Caroline ^{[7
]}

Lan, Joung-Liang ^{[8
]}

Fang, Yao-Fan ^{[9
]}

Chang, Edmund ^{[10
]}

Yousefpour, Noosha ^{[10
]}

Low, Julian ^{[10
]}

Bao, Min ^{[10
]}

Chang, Qing ^{[10
]}

Osterloh, Jeannette ^{[10
]}

Mongan, Ann ^{[10
]}

Yednock, Ted ^{[10
]}

Artis, Dean ^{[10
]}

Andrews-Zwilling, Yaisa ^{[10
]}

Kroon, Henk-Andre ^{[10
]}

机构：

[1] Univ Calif San Francisco, San Francisco, CA USA

[2] St Lukes Med Ctr, Quezon City, Philippines

[3] Tri Serv Gen Hosp, Taipei, Taiwan

[4] Angeles Univ Fdn, Med Ctr, Pampanga, Philippines

[5] Med Ctr Manila, Manila, Philippines

[6] Univ Philippines Manila, Manila, Philippines

[7] Iloilo Doctors Hosp, Iloilo, Philippines

[8] China Med Univ Hosp, Taichung, Taiwan

[9] Chang Gung Mem Hosp, Linkou, Taiwan

[10] Annexon Biosci, Brisbane, CA USA

来源：

ARTHRITIS & RHEUMATOLOGY | 2023年 / 75卷

关键词：

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

2338

引用

页码：4632 / 4633

页数：2

共 4 条

[1] Pathogenic Anti-C1q Antibodies Potentiate Activation of the Classical Complement Pathway in a Subset of Lupus Nephritis Patients
Chang, Edmund
Low, Julian
Cahir-McFarland, Ellen
Kroon, Henk-Andre
Andrews-Zwilling, Yaisa
Yednock, Ted
Mongan, Ann
ARTHRITIS & RHEUMATOLOGY, 2022, 74 : 1292 - 1294
[2] Anti-C1q autoantibodies from active lupus nephritis patients could inhibit the clearance of apoptotic cells and complement classical pathway activation mediated by C1q in vitro
Pang, Yun
Yang, Xiao-Wei
Song, Yan
Yu, Feng
Zhao, Ming-Hui
IMMUNOBIOLOGY, 2014, 219 (12) : 980 - 989
[3] C1q A08 Is a Half-Cryptic Epitope of Anti-C1q A08 Antibodies in Lupus Nephritis and Important for the Activation of Complement Classical Pathway
Wu, Wen-Jun
Tan, Ying
Liu, Xiao-Ling
Yu, Feng
Zhao, Ming-Hui
FRONTIERS IN IMMUNOLOGY, 2020, 11
[4] Inhibition of C1q, Initiator of the Classical Complement Cascade, by ANX005 for the Treatment of Guillain-Barre Syndrome: Results from a Phase 1b Study
Islam, Zhahirul
Papri, Nowshin
Jahan, Israt
Azad, Khan Abul Kalam
Kroon, Henk-Andre
Humphriss, Eric
Sankaranarayanan, Sethu
Yednock, Ted
Keswani, Sanjay
Mohammad, Quazi Deen
NEUROLOGY, 2020, 94 (15)

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