Antibody-mediated Rejection in Kidney Transplant: An Unmastered Area

被引:0
|
作者
Valavoor, Shahul [1 ]
Anand, Manish [1 ]
Govil, Amit [1 ]
机构
[1] Univ Cincinnati, Coll Med, Div Nephrol, Cincinnati, OH USA
关键词
ABMR; antibody-mediated rejection; donor-specific antibody; rejection; DONOR-SPECIFIC ANTIBODY; COMPLEMENT; MANAGEMENT; BIOPSIES; TISSUE;
D O I
10.4103/ijot.ijot_129_23
中图分类号
R3 [基础医学]; R4 [临床医学];
学科分类号
1001 ; 1002 ; 100602 ;
摘要
Antibody-mediated rejection (ABMR) remains a significant cause of allograft failure in patients with kidney transplantation. Despite successful strategies to treat ABMR, irreversible injury in the form of transplant glomerulopathy commonly manifests months to years later. Treatment for ABMR is not standardized, and treatment guidelines vary among different transplant centers. The outcomes for patients at risk for ABMR have not significantly changed over the years. This is largely because of an incomplete understanding of the mechanisms of injury responsible for different phenotypes of ABMR. Establishing relevant surrogate endpoints to facilitate more informative studies will likely allow for a more accurate determination of prognosis and pave the way for new and effective therapeutic approaches. This article aims to summarize the current understanding of the mechanism of injury in ABMR and highlight current diagnostic approaches and treatment strategies.
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页数:9
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