RNA-binding proteins in bone pathophysiology

被引:0
|
作者
Maroni, Paola [1 ]
Pesce, Noemi Anna [1 ]
Lombardi, Giovanni [1 ,2 ]
机构
[1] IRCCS Ist Ortoped Galeazzi, Lab Expt Biochem & Mol Biol, Milan, Italy
[2] Poznan Univ Phys Educ, Dept Athlet Strength & Conditioning, Poznan, Poland
关键词
RNA binding proteins (RBPs); bone pathophysiology; post-transcriptional regulatory mechanisms; modulation of mRNAs; osteoporosis; bone aging; bone cancer; bone metastasis; TRANSLATION INITIATION; HNRNP A1; OSTEOSARCOMA CELLS; RECOGNITION MOTIF; GENE-EXPRESSION; STEM-CELLS; MIGRATION; INVASION; SAM68; POLYADENYLATION;
D O I
10.3389/fcell.2024.1412268
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Bone remodelling is a highly regulated process that maintains mineral homeostasis and preserves bone integrity. During this process, intricate communication among all bone cells is required. Indeed, adapt to changing functional situations in the bone, the resorption activity of osteoclasts is tightly balanced with the bone formation activity of osteoblasts. Recent studies have reported that RNA Binding Proteins (RBPs) are involved in bone cell activity regulation. RBPs are critical effectors of gene expression and essential regulators of cell fate decision, due to their ability to bind and regulate the activity of cellular RNAs. Thus, a better understanding of these regulation mechanisms at molecular and cellular levels could generate new knowledge on the pathophysiologic conditions of bone. In this Review, we provide an overview of the basic properties and functions of selected RBPs, focusing on their physiological and pathological roles in the bone.
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页数:13
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