Impact of neoadjuvant chemotherapy on short-term outcomes after simple and complex minimally invasive minor hepatectomy for colorectal liver metastases: A propensity-score matched and coarsened exact matched study

被引：0

作者：

Hoogteijling, Tijs J. ^{[1
,2
]}

Abu Hilal, Mohammad ^{[1
,3
]}

Zimmitti, Giuseppe ^{[1
]}

Aghayan, Davit L. ^{[4
,5
]}

Wu, Andrew G. R. ^{[6
]}

Cipriani, Federica ^{[7
]}

Gruttadauria, Salvatore ^{[8
,9
]}

Scatton, Olivier ^{[10
]}

Long, Tran Cong Duy ^{[11
]}

Herman, Paulo ^{[12
]}

Marino, Marco V. ^{[13
,74
]}

Mazzaferro, Vincenzo ^{[14
,15
]}

Chiow, Adrian K. H. ^{[16
]}

Sucandy, Iswanto ^{[17
]}

Ivanecz, Arpad ^{[18
]}

Choi, Sung Hoon ^{[19
]}

Lee, Jae Hoon ^{[20
]}

Gastaca, Mikel ^{[21
]}

Vivarelli, Marcot ^{[20
,22
]}

Giuliante, Felice ^{[23
]}

Ruzzenente, Andrea ^{[24
]}

Yong, Chee Chien ^{[25
]}

Yin, Mengqiu ^{[26
]}

Fondevila, Constantino ^{[27
,72
]}

Efanov, Mikhail ^{[28
]}

Morise, Zenichi ^{[29
]}

Di Benedetto, Fabrizio ^{[30
]}

Brustia, Raffaele ^{[31
]}

Dalla Valle, Raffaele ^{[32
]}

Boggi, Ugo ^{[33
]}

Geller, David ^{[34
]}

Belli, Andrea ^{[35
]}

Memeo, Riccardo ^{[36
]}

Mejia, Alejandro ^{[37
]}

Park, James O. ^{[38
]}

Rotellar, Fernando ^{[39
,73
]}

Choi, Gi Hong ^{[40
]}

Robles-Campos, Ricardo ^{[41
]}

Wang, Xiaoying ^{[42
]}

Sutcliffe, Robert P. ^{[43
]}

Pratschke, Johann ^{[44
,45
,46
,47
]}

Tang, Chung-Ngai ^{[48
]}

Chong, Charing C. N. ^{[49
]}

Hondt, Mathieu ^{[50
]}

Monden, Kazuteru ^{[51
]}

Lopez-Ben, Santiago ^{[52
]}

Kingham, T. Peter ^{[53
]}

Ferrero, Alessandro ^{[54
]}

Ettorre, Giuseppe Maria ^{[55
]}

Cherqui, Daniel ^{[56
]}

机构：

[1] Fdn Poliambulanza Inst Osped, Dept Surg, Brescia, Italy

[2] Locat Univ Amsterdam, Dept Surg, Amsterdam UMC, Amsterdam, Netherlands

[3] Univ Hosp Southampton, Dept Surg, Southampton, Hants, England

[4] Univ Oslo, Oslo Univ Hosp, Inst Clin Med, Intervent Ctr, Oslo, Norway

[5] Univ Oslo, Oslo Univ Hosp, Inst Clin Med, Dept HPB Surg, Oslo, Norway

[6] Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore, Singapore

[7] IRCCS San Raffaele Hosp, Hepatobiliary Surg Div, Milan, Italy

[8] Univ Pittsburgh, Med Ctr Italy, Dept Treatment & Study Abdominal Dis & Abdominal, Ist Ricovero &Cura Carattere Sci Ist Mediterraneo, Palermo, Italy

[9] Univ Catania, Dept Gen Surg & Med Surg Specialties, Catania, Italy

[10] Sorbonne Univ, Hop Pitie Salpetriere, Dept Digest HBP & Liver Transplantat, Paris, France

[11] Univ Med & Pharm, Univ Med Ctr, Dept Hepatopancreatobiliary Surg, Ho Chi Minh City, Vietnam

[12] Univ Sao Paulo, Dept Gastroenterol, Sch Med, Liver Surg Unit, Sao Paulo, Brazil

[13] Azienda Osped Osped Riuniti Villa Sofia Cervello, Dept Gen Surg, Palermo, Italy

[14] Fdn IRCCS Ist Nazl Tumori Milano, HPB Surg & Liver Transplantat, Milan, Italy

[15] Univ Milan, Milan, Italy

[16] Changi Gen Hosp, Dept Surg, Hepatopancreatobiliary Unit, Singapore, Singapore

[17] AdventHlth Tampa, Digest Hlth Inst, Tampa, FL USA

[18] Univ Med Ctr Maribor, Dept Abdominal & Gen Surg, Maribor, Slovenia

[19] CHA Univ, Sch Med, CHA Bundang Med Ctr, Dept Gen Surg, Seongnam, South Korea

[20] Univ Ulsan, Div Hepatobiliary & Pancreat Surg, Dept Surg, Asan Med Ctr,Coll Med, Seoul, South Korea

[21] Univ Basque Country, Cruces Univ Hosp, Biocruces Bizkaia Hlth Res Inst, Hepatobiliary Surg & Liver Transplantat Unit, Bilbao, Spain

[22] Polytech Univ Marche, United Hosp Ancona, HPB Surg & Transplantat Unit, Dept Expt & Clin Med, Ancona, Italy

[23] Univ Cattolica Sacro Cuore, Hepatobiliary Surg Unit, Fdn Policlin Univ A Gemelli, IRCCS, Rome, Italy

[24] Univ Verona, GB Rossi Hosp, Dept Surg Dent Gynecol & Pediat, Gen & Hepatobiliary Surg, Verona, Italy

[25] Chang Gung Mem Hosp, Dept Surg, Kaohsiung, Taiwan

[26] Zhejiang Univ, Affiliated Jinhua Hosp, Dept Hepatobiliary Surg, Sch Med, Jinhua, Zhejiang, Peoples R China

[27] Hosp Univ La Paz, Gen & Digest Surg, IdiPAZ, Madrid, Spain

[28] Moscow Clin Sci Ctr, Dept Hepatopancreatobiliary Surg, Moscow, Russia

[29] Fujita Hlth Univ, Sch Med, Dept Surg, Okazaki Med Ctr, Okazaki, Aichi, Japan

[30] Univ Modena & Reggio Emilia, HPB Surg & Liver Transplant Unit, Modena, Italy

[31] Henri Mondor Hosp, AP HP, Dept Digest & Hepatobiliary & Pancreat Surg, Creteil, France

[32] Univ Parma, Dept Med & Surg, Hepatobiliary Surg Unit, Parma, Italy

[33] Univ Pisa, Div Gen & Transplant Surg, Pisa, Italy

[34] Univ Pittsburgh, Div Hepatobiliary & Pancreat Surg, Dept Surg, Med Ctr, Pittsburgh, PA USA

[35] Natl Canc Ctr IRCCS G Pascale, Div Hepatopancreatobiliary Surg Oncol, Dept Abdominal Oncol, Naples, Italy

[36] F Miulli Gen Reg Hosp, Unit Hepatopancreatc Biliary Surg, Bari, Italy

[37] Methodist Dallas Med Ctr, Liver Inst, Dallas, TX USA

[38] Univ Washington, Dept Surg, Med Ctr, Seattle, WA USA

[39] Univ Navarra, Dept Gen Surg, HPB & Liver Transplant Unit, Univ Navarra Clin, Pamplona, Spain

[40] Yonsei Univ, Severance Hosp, Div Hepatopancreatobiliary Surg, Dept Surg,Coll Med, Seoul, South Korea

[41] Clin & Univ Hosp Virgen Arrixaca, IMIB ARRIXACA, Dept Gen Visceral & Transplantat Surg, Murcia, Spain

[42] Fudan Univ, Liver Canc Inst, Zhongshan Hosp, Dept Liver Surg & Transplantat, Shanghai, Peoples R China

[43] Univ Hosp Birmingham NHS Fdn Trust, Dept Hepatopancreatobiliary & Liver Transplant Su, Birmingham, W Midlands, England

[44] Charite Univ Med Berlin, Dept Surg, Campus Charite Mitte, Berlin, Germany

[45] Charite Univ Med Berlin, Campus Virchow Klinikum, Berlin, Germany

[46] Free Univ Berlin, Berlin, Germany

[47] Berlin Inst Hlth, Berlin, Germany

[48] Pamela Youde Nethersole Eastern Hosp, Dept Surg, Hong Kong, Peoples R China

[49] Chinese Univ Hong Kong, Dept Surg, Prince Wales Hosp, Hong Kong, Peoples R China

[50] Groeninge Hosp, Dept Digest & Hepatobiliary Pancreat Surg, Kortrijk, Belgium

来源：

EJSO | 2024年 / 50卷 / 06期

关键词：

Neoadjuvant chemotherapy; Colorectal liver metastases; Minor hepatectomy; Difficulty score; Minimally invasive liver surgery; Coarsened exact-matched; Propensity-score matched; Inverse probability treatment weighting; RANDOMIZED CONTROLLED-TRIALS; PREOPERATIVE CHEMOTHERAPY; HEPATIC RESECTION; SURGICAL OUTCOMES; DIFFICULTY; CANCER; SURGERY; RECOMMENDATIONS; OXALIPLATIN; HISTOLOGY;

D O I：

10.1016/j.ejso.2024.108309

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: In the last three decades, minimally invasive liver resection has been replacing conventional open approach in liver surgery. More recently, developments in neoadjuvant chemotherapy have led to increased multidisciplinary management of colorectal liver metastases with both medical and surgical treatment modalities. However, the impact of neoadjuvant chemotherapy on the surgical outcomes of minimally invasive liver resections remains poorly understood. Methods: A multicenter, international, database of 4998 minimally invasive minor hepatectomy for colorectal liver metastases was used to compare surgical outcomes in patients who received neoadjuvant chemotherapy with surgery alone. To correct for baseline imbalance, propensity score matching, coarsened exact matching and inverse probability treatment weighting were performed. Results: 2546 patients met the inclusion criteria. After propensity score matching there were 759 patients in both groups and 383 patients in both groups after coarsened exact matching. Baseline characteristics were equal after both matching strategies. Neoadjuvant chemotherapy was not associated with statistically significant worse surgical outcomes of minimally invasive minor hepatectomy. Conclusion: Neoadjuvant chemotherapy had no statistically significant impact on short-term surgical outcomes after simple and complex minimally invasive minor hepatectomy for colorectal liver metastases.

引用

页数：10

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