Tumor immune escape by autotaxin: keeping eosinophils at bay

被引：1
|
作者：
Matas-Rico, Elisa [1 ]
Moolenaar, Wouter H. [2 ]
机构：
[1] Univ Malaga, Dept Cell Biol Genet & Physiol, Malaga, Spain
[2] Netherlands Canc Inst, Div Biochem, Plesmanlaan, Amsterdam, Netherlands
来源：
TRENDS IN CANCER | 2024年 / 10卷 / 04期
关键词：
D O I：
10.1016/j.trecan.2024.03.002
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Secreted autotaxin (ATX) promotes tumor progression by producing the pleiotropic lipid mediator lysophosphatidic acid (LPA). In a recent Nature Cancer paper, Bhattacharyya et al. show that ATX/LPA signaling suppresses CCL11-driven infiltration of eosinophils into the pancreatic tumor microenvironment to facilitate tumor progression, thus revealing a new ATX-mediated immune escape mechanism and highlighting the antitumor potential of eosinophils.
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收藏
页码：283 / 285
页数：3
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