COMPUTATIONAL SIMULATION OF CALCIUM PEROXIDE BASED HYDROGELS AS AN OXYGEN-GENERATING SCAFFOLDS FOR WOUND HEALING

Finite element methods are now widely used to solve structural, fluid and multi-physics problems numerically[1]. The methods are used extensively because engineers and scientists can mathematically model and numerically solve very complex problems especially in biomedical related fields. Biomimetic hydrogels have been developed in the fabrication of multifunctional microenvironments for cell culture and tissue fabrication. In the current study, different concentrations of Calcium peroxide (CaO2) were incorporated in Carboxy-methylcellulose (CMC)/Gelatin hydrogels to enhance the wound healing procedure by releasing oxygen to the epidermis. A bright comparison between different concentrations of CaO2 was investigated. By increasing the concentration of CaO2, the concentration of Oxygen increased; however, the optimum concentration was investigated to be 0.5 mol/mg. In addition, it was shown that there is a clear difference in healing procedure of wounds with hydrogel or without it. The result of this study demonstrates that CMC/Gelatin/ CaO2 would be an idol scaffold for wound healing due to its oxygen-generating property.