Principle, application and challenges of development siRNA-based therapeutics against bacterial and viral infections: a comprehensive review

被引:0
|
作者
Motamedi, Hamid [1 ,2 ]
Ari, Marzie Mahdizade [3 ,4 ]
Alvandi, Amirhoushang [1 ,5 ]
Abiri, Ramin [1 ,6 ]
机构
[1] Kermanshah Univ Med Sci, Student Res Comm, Sch Med, Kermanshah, Iran
[2] Kermanshah Univ Med Sci, Sch Med, Dept Microbiol, Kermanshah, Iran
[3] Iran Univ Med Sci, Sch Med, Dept Microbiol, Tehran, Iran
[4] Iran Univ Med Sci, Microbial Biotechnol Res Ctr, Tehran, Iran
[5] Kermanshah Univ Med Sci, Hlth Technol Inst, Med Technol Res Ctr, Kermanshah, Iran
[6] Kermanshah Univ Med Sci, Hlth Technol Inst, Fertil & Infertil Res Ctr, Kermanshah, Iran
关键词
RNAi; siRNA; non-coding RNA; delivery systems; therapeutic applications; HEPATITIS-C VIRUS; SMALL INTERFERING RNA; CENTRAL-NERVOUS-SYSTEM; LONG NONCODING RNAS; HUMAN BREAST-CANCER; IN-VIVO DELIVERY; GENE-EXPRESSION; NUCLEIC-ACID; CHEMICAL-MODIFICATION; PROTEIN EXPRESSION;
D O I
10.3389/fmicb.2024.1393646
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
While significant progress has been made in understanding and applying gene silencing mechanisms and the treatment of human diseases, there have been still several obstacles in therapeutic use. For the first time, ONPATTRO, as the first small interfering RNA (siRNA) based drug was invented in 2018 for treatment of hTTR with polyneuropathy. Additionally, four other siRNA based drugs naming Givosiran, Inclisiran, Lumasiran, and Vutrisiran have been approved by the US Food and Drug Administration and the European Medicines Agency for clinical use by hitherto. In this review, we have discussed the key and promising advances in the development of siRNA-based drugs in preclinical and clinical stages, the impact of these molecules in bacterial and viral infection diseases, delivery system issues, the impact of administration methods, limitations of siRNA application and how to overcome them and a glimpse into future developments.
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页数:23
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