Computational assessment of potential nonpeptidic inhibitors for PLK1 polo-box domain

被引：0
|
作者：
Kucukkal, Tugba G. [1 ]
Lawal, Monsurat [1 ]
机构：
[1] Gallaudet Univ, Washington, DC USA
来源：
BIOPHYSICAL JOURNAL | 2024年 / 123卷 / 03期
关键词：
D O I：
暂无
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
2633-Pos
引用
收藏
页码：470A / 470A
页数：1
相关论文
共 50 条
  • [1] Inhibitors of the PLK1 polo-box domain: drug design strategies and therapeutic opportunities in cancer
    Stafford, Jessy M.
    Wyatt, Michael D.
    McInnes, Campbell
    EXPERT OPINION ON DRUG DISCOVERY, 2023, 18 (01) : 65 - 81
  • [2] Differential Cellular Effects of Plk1 Inhibitors Targeting the ATP-binding Domain or Polo-box Domain
    Shin, Sol-Bi
    Woo, Sang-Uk
    Yim, Hyungshin
    JOURNAL OF CELLULAR PHYSIOLOGY, 2015, 230 (12) : 3057 - 3067
  • [3] Probing monomer - dimer and conformational transitions of PLK1 using catalytic and polo-box domain inhibitors
    Sanhaji, Mourad
    Raab, Monika
    Merhej, George
    Rao, Chintada Nageswara
    Babic, Ivan
    Nurmemmedov, Elmar
    Strebhardt, Klaus
    Wyatt, MIchael
    McInnes, Campbell
    CANCER RESEARCH, 2024, 84 (06)
  • [4] Nonpeptidic, Polo-Box Domain-Targeted Inhibitors of PLK1 Block Kinase Activity, Induce Its Degradation and Target-Resistant Cells
    Chapagai, Danda
    Ramamoorthy, Gurusankar
    Varghese, Jessy
    Nurmemmedov, Elmar
    McInnes, Campbell
    Wyatt, Michael D.
    JOURNAL OF MEDICINAL CHEMISTRY, 2021, 64 (14) : 9916 - 9925
  • [5] Polo-box of Plk1 inhibits proliferation of cancer cell
    Yuan, J
    Krämer, A
    Eckerdt, F
    Kaufmann, M
    Strebhardt, K
    CELL MOTILITY AND THE CYTOSKELETON, 2003, 54 (02): : 192 - 192
  • [6] Several inhibitors of the Plk1 Polo-Box Domain turn out to be non-specific protein alkylators
    Archambault, Vincent
    Normandin, Karine
    CELL CYCLE, 2017, 16 (12) : 1220 - 1224
  • [7] Structural Optimization and Anticancer Activity of Polo-like Kinase 1 (Plk1) Polo-Box Domain (PBD) Inhibitors and Their Prodrugs
    Park, Jung-Eun
    Lee, Hobin
    Oliva, Paola
    Kirsch, Klara
    Kim, Bora
    Ahn, Jong Il
    Alverez, Celeste N.
    Gaikwad, Snehal
    Krausz, Kristopher W.
    O'Connor, Robert
    Rai, Ganesha
    Simeonov, Anton
    Mock, Beverly A.
    Gonzalez, Frank J.
    Lee, Kyung S.
    Jacobson, Kenneth A.
    ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE, 2023, 6 (03) : 422 - 446
  • [8] Modulation of the Allosteric Communication between the Polo-Box Domain and the Catalytic Domain in Plk1 by Small Compounds
    Raab, Monika
    Sanhaji, Mourad
    Pietsch, Larissa
    Bequignon, Isabelle
    Herbrand, Amanda K.
    Suess, Evelyn
    Gande, Santosh L.
    Caspar, Birgit
    Kudlinzki, Denis
    Saxena, Krishna
    Sreeramulu, Sridhar
    Schwalbe, Harald
    Strebhardt, Klaus
    Biondi, Ricardo M.
    ACS CHEMICAL BIOLOGY, 2018, 13 (08) : 1921 - 1931
  • [9] Computational Analysis of Phosphopeptide Binding to the Polo-Box Domain of the Mitotic Kinase PLK1 Using Molecular Dynamics Simulation
    Huggins, David J.
    McKenzie, Grahame J.
    Robinson, Daniel D.
    Narvaez, Ana J.
    Hardwick, Bryn
    Roberts-Thomson, Meredith
    Venkitaraman, Ashok R.
    Grant, Guy H.
    Payne, Mike C.
    PLOS COMPUTATIONAL BIOLOGY, 2010, 6 (08)
  • [10] Thymoquinone Blocks pSer/pThr Recognition by Plk1 Polo-Box Domain As a Phosohate Mimic
    Yin, Zhou
    Song, Yunlong
    Rehse, Peter H.
    ACS CHEMICAL BIOLOGY, 2013, 8 (02) : 303 - 308
12345