Inclusion of dilution quality control samples in quantitative LC-MS bioanalysis

被引：0
|
作者：
Li, Wenkui [1 ]
Fu, Yunlin [1 ]
Picard, Franck [2 ]
机构：
[1] Novartis Biomed Res, Pharmacokinet Sci, E Hanover, NJ 07936 USA
[2] Novartis Biomed Res, Pharmacokinet Sci, CH-4056 Basel, Switzerland
来源：
BIOANALYSIS | 2024年 / 16卷 / 17-18期
关键词：
bioanalysis; dilution; dilution factor; dilution integrity; dilution QCs; LC-MS; pre-dilution; SMALL-MOLECULE;
D O I：
10.1080/17576180.2024.2352253
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
In LC-MS bioanalysis, sample dilution plays various roles, including bringing analyte concentrations within the validated/qualified dynamic range or alleviating matrix effect for accurate determination of the target analyte(s) in the intended study samples. Adherence to health authority requirements, incorporating good dilution practices, and timely demonstration of dilution integrity whenever samples are diluted in an analytical run are essential to ensure the reliability of bioanalytical results.
引用
收藏
页码：923 / 925
页数：3
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