cAMP-related migraine attacks occur without activation of CGRP receptors

被引：0
|
作者：
Kessing, Richard
机构：
来源：
FORTSCHRITTE DER NEUROLOGIE PSYCHIATRIE | 2024年 / 92卷 / 05期
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D O I：
10.1055/a-2247-9858
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Das Calcitonin-Gene-Related-Peptide (CGRP) wurde als Schlusselsubstanz zur Aktivierung von cAMP in einer nachgeschalteten Signalkaskade identifiziert, die am Migraneanfall beteiligt ist. Unklar ist jedoch, ob die intrazellulare cAMP-Signalgebung wahrend eines Migraneanfalls beim Menschen eine CGRP-Rezeptoraktivierung erfordert. Eine danische Arbeitsgruppe wollte dies durch den Einsatz menschlicher Provokationsmodelle klaren.
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页码：163 / 164
页数：2
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