5,10,15,20-Tetrakis-(4-(3-carbamoyl-pyridyl)-methylphenyl)porphyrin Bromide

被引：0

作者：

Satta, Giuseppe ^{[1
,2
]}

Gaspa, Silvia ^{[1
]}

Pisano, Luisa ^{[1
,2
]}

De Luca, Lidia ^{[1
]}

Carraro, Massimo ^{[1
,2
]}

机构：

[1] Univ Sassari, Dept Chem Phys Math & Nat Sci, Via Vienna 2, I-07100 Sassari, Italy

[2] Consorzio Interuniv Reatt Chim & Catalisi CIRCC, Via Celso Ulpiani 27, I-70126 Bari, Italy

来源：

MOLBANK | 2024年 / 2024卷 / 02期

关键词：

porphyrin; ligand; g-quadruplex; macrocycle; pyrrole; synthesis; QUADRUPLEX; DNA;

D O I：

10.3390/M1836

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of a new tetracationic porphyrin derivative is described. Contrary to the best known derivatives in the literature, which are derived from 5,10,15,20-tetrakis-4-pyridylporphyrin (TPyP), in this procedure we start from 5,10,15,20-tetrakis-(4-carboxymethoxyphenyl)porphyrin (TPPCOOMe), obtained by the condensation reaction between pyrrole and 4-formylbenzoate. The reaction is carried out in refluxed xylene, avoiding the use of halogenated solvents. The final product, 5,10,15,20-tetrakis-(4-(3-carbamoyl-pyridyl)-methylphenyl)porphyrin bromide (P15p), exhibits four cationic portions that make it soluble in water and suitable for G4 stabilization. The choice to synthesize a derivative of TPPCOOMe is based on the idea of having a possible stabilizer that, unlike those obtained from TPyP, shows the cationic moieties farther from the porphyrin core and thus closer to the phosphate groups present on the G4 loops.

引用

页数：6

共 50 条

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