Animal models of tendon calcification: Past, present, and future

被引:1
|
作者
Li, Ruichen [1 ]
Lai, Canhao [1 ]
Luo, Hong [1 ]
Lan, Yujian [1 ]
Duan, Xinfang [1 ]
Bao, Dingsu [1 ,2 ]
Hou, Zhipeng [1 ]
Liu, Huan [1 ]
Fu, Shijie [1 ]
机构
[1] Southwest Med Univ, Affiliated Tradit Chinese Med Hosp, Dept Bone & Joint, Luzhou 646000, Peoples R China
[2] Chengdu Univ Tradit Chinese Med, Chengdu, Peoples R China
基金
中国博士后科学基金;
关键词
animal models; review; tendon calcification; FIBRODYSPLASIA OSSIFICANS PROGRESSIVA; GROWTH-FACTOR-BETA; HETEROTOPIC OSSIFICATION; BONE-FORMATION; ACHILLES-TENDON; ROTATOR CUFF; STEM-CELLS; STEM/PROGENITOR CELLS; EXTRACELLULAR-MATRIX; ECTOPIC OSSIFICATION;
D O I
10.1002/ame2.12439
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Tendon calcification is a common clinical condition that frequently occurs as a complication after tendon injury and surgery, or as an expression of fibrodysplasia ossificans progressiva. This condition can be referred to by various names in clinical practice and literature, including tendon ossification, tendon mineralization, heterotopic ossification, and calcific tendonitis. The exact pathogenesis of tendon calcification remains uncertain, but current mainstream research suggests that calcification is mostly cell mediated. To further elucidate the pathogenesis of tendon calcification and to better simulate the overall process, selecting appropriate experimental animal models is important. Numerous animal models have been utilized in various clinical studies, each with its own set of advantages and limitations. In this review, we have discussed the advancements made in research on animal models of tendon calcification, with a focus on the selection of experimental animals, the sites of injury in these models, and the methods employed for modeling. Various modeling methods for experimental animal models of tendon calcification are shown in the figure: the methods of modeling tendon calcification in experimental animals as shown in the figure can be mainly classified as trauma induced, tissue factor injections, dietary or pharmacological modifications, and gene knockouts.image
引用
收藏
页码:471 / 483
页数:13
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