Structural Characters and Pharmacological Activity of Protopanaxadiol-Type Saponins and Protopanaxatriol-Type Saponins from Ginseng

被引：1
|
作者：
Zhang, Lancao [1 ]
Gao, Xiang [2 ]
Yang, Chunhui [1 ,3 ]
Liang, Zuguo [2 ]
Guan, Dongsong [1 ,4 ]
Yuan, Tongyi [2 ]
Qi, Wenxiu [1 ]
Zhao, Daqing [1 ]
Li, Xiangyan [1 ]
Dong, Haisi [1 ]
Zhang, He [1 ,2 ,5 ]
机构：
[1] Changchun Univ Chinese Med, Northeast Asia Res Inst Tradit Chinese Med, Changchun 130117, Peoples R China
[2] Changchun Univ Chinese Med, Coll Pharm, Changchun 130017, Peoples R China
[3] Changchun Univ Tradit Chinese Med, Tuina Dept, Affiliated Hosp 3, Changchun 130117, Peoples R China
[4] Qual Testing Lab, Haerbin Customs Dist, Foshan 150008, Peoples R China
[5] Changchun Univ Chinese Med, Res Ctr Tradit Chinese Med, Affiliated Hosp, Changchun 130021, Peoples R China
来源：
ADVANCES IN PHARMACOLOGICAL AND PHARMACEUTICAL SCIENCES | 2024年 / 2024卷
基金：
中国国家自然科学基金;
关键词：
INHIBITS PLATELET ACTIVATION; NF-KAPPA-B; COMPOUND K; ALZHEIMERS-DISEASE; IN-VITRO; PROVIDES NEUROPROTECTION; MASS-SPECTROMETRY; INDUCED APOPTOSIS; OXIDATIVE STRESS; RED GINSENG;
D O I：
10.1155/2024/9096774
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Ginseng has a long history of drug application in China, which can treat various diseases and achieve significant efficacy. Ginsenosides have always been deemed important ingredients for pharmacological activities. Based on the structural characteristics of steroidal saponins, ginsenosides are mainly divided into protopanaxadiol-type saponins (PDS, mainly including Rb1, Rb2, Rd, Rc, Rh2, CK, and PPD) and protopanaxatriol-type saponins (PTS, mainly including Re, R1, Rg1, Rh1, Rf, and PPT). The structure differences between PDS and PTS result in the differences of pharmacological activities. This paper provides an overview of PDS and PTS, mainly focusing on their chemical profile, pharmacokinetics, hydrolytic metabolism, and pharmacological activities including antioxidant, antifatigue, antiaging, immunodulation, antitumor, cardiovascular protection, neuroprotection, and antidiabetes. It is intended to contribute to an in-depth study of the relationship between PDS and PTS.
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页数：17
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