Selective binding of c-MYC G-quadruplex caged in a dsDNA by a hemopeptide

被引：0
|
作者：
Massalha, Leen [1 ,2 ]
Levin, Adiel Richter [1 ,2 ]
Adiram-Filiba, Nurit [1 ,2 ]
Golub, Eyal [1 ,2 ]
机构：
[1] Bar Ilan Univ, Fac Exact Sci, Dept Chem, IL-5290002 Ramat Gan, Israel
[2] Bar Ilan Univ, Inst Nanotechnol & Adv Mat, IL-5290002 Ramat Gan, Israel
来源：
CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 60期
关键词：
DNA; HEMOPROTEINS; INSIGHTS; MOTIFS;
D O I：
10.1039/d4cc01389a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The microperoxidase-11 hemopeptide exhibits configuration-dependent selectivity for guanine-quadruplexes by specifically uncaging c-MYC guanine-quadruplexes from a duplex DNA. A hemopeptide ligand for G-quadruplex exhibits selective binding towards c-MYC GQ caged inside a double-stranded DNA configuration via a synergistic interplay between the heme moiety and peptide chain.
引用
收藏
页码：7769 / 7772
页数：4
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