Longitudinal Study of Different Progression Patterns in High-Risk Cutaneous Squamous Cell Carcinoma

被引:0
|
作者
Tejera-Vaquerizo, A. [1 ,2 ]
Canueto, J. [3 ]
Gomez-Tomas, A. [4 ]
Santos-Juanes, J. [5 ,6 ]
Ribero, S. [7 ]
Avallone, G. [7 ]
Jaka, A. [8 ]
Ferrandiz-Pulido, C. [4 ]
Toll, A. [9 ]
Sanmartin, O. [10 ]
机构
[1] Hosp San Juan Dios, Unidad Oncol Cutanea, Cordoba, Spain
[2] Inst Dermatol GlobalDerm, Serv Dermatol, Palma Del Rio, Cordoba, Spain
[3] Complejo Asistencial Univ Salamanca, Serv Dermatol, Salamanca, Spain
[4] Univ Autonoma Barcelona, Hosp Univ Vall dHebron, Serv Dermatol, Barcelona, Spain
[5] Univ Oviedo, Hosp Cent Asturias Inst, Serv Dermatol, IUOPA, Oviedo, Spain
[6] Univ Oviedo, Inst Invest Sanit del Principado Asturias, IUOPA, Oviedo, Spain
[7] Univ Turin, Med Sci Dept, Sect Dermatol, Turin, Italy
[8] Univ Autonoma Barcelona, Hosp Univ Germans Trias & Pujol, Serv Dermatol, Inst Invest Germans Triasi & Pujol, Badalona, Barcelona, Spain
[9] Univ Barcelona, Hosp Clin, Serv Dermatol, Barcelona, Spain
[10] Inst Valenciano Oncol, Serv Dermatol, Valencia, Spain
来源
ACTAS DERMO-SIFILIOGRAFICAS | 2024年 / 115卷 / 07期
关键词
Cutaneous squamous cell carcinoma; Prognosis; Neoplastic metastasis; Lymphatic metastasis; Disease progression; CANCER METASTASIS; NODE BIOPSY; LYMPHADENECTOMY;
D O I
10.1016/j.ad.2024.03.018
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background and objective: Cutaneous squamous cell carcinoma (cSCC) is the second leading cause of skin cancer mortality in Europe. Few studies have analyzed the different pathways of this tumor progression in its natural history. The main objective of this study was to analyze the different metastatic and progression pathways and their temporal occurrence in the evolution of cSCC. Material and method: We conducted a multicenter, retrospective, and observational study of consecutive high-risk sSCCs included in the SQUAMATA project. Results: A total of 222 out of the 1346 patients included relapsed. The most frequent route of progression was the lymphatic one (62.6%). A total of 20.2% of the cases with lymphatic progression developed distant metastases. Only 1 case (3.1%) of distant metastasis followed local recurrence without previous lymphatic metastasis. The median time to disease-related mortality was longer in patients who developed systemic metastases than in those who died of locoregional progression. Conclusions: The mortality of patients with cSCC is mostly due to the regional progression of their lymphatic metastases. The appearance of distant metastases is practically always (96.9%) associated with previous lymphatic metastatic progression. Therefore, in the future, new studies will be needed to assess the regional management of cSCC in both surgical and adjuvant therapies. (c) 2024 AEDV. Published by Elsevier Espana, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
引用
收藏
页码:670 / 678
页数:9
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