Promoter methylation of tumor suppressor genes in esophageal squamous cell carcinoma

被引：0

作者：

JiSheng Li ^{[1
]}

JianMing Ying ^{[2
]}

XiuWen Wang ^{[1
]}

ZhaoHui Wang ^{[3
,4
,5
]}

Qian Tao ^{[3
,4
,5
]}

LiLi Li ^{[3
,4
,5
]}

机构：

[1] Department of Chemotherapy,Cancer Center,Qilu Hospital,Shandong University

[2] Department of Pathology,Cancer Hospital & Institute,Peking Union Medical College and Chinese Academy of Medical Sciences

[3] Cancer Epigenetics Laboratory,Department of Clinical Oncology,Sir YK Pao Center for Cancer and Li Ka Shing Institute of Health Sciences,The Chinese University of Hong Kong

[4] Hong Kong and CUHK Shenzhen Research Institute

[5] Shenzhen Institutes of Advanced Technology,Chinese Academy of

来源：

Chinese Journal of Cancer. | 2013年 / 32卷 / 01期

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Esophageal squamous cell carcinoma(ESCC) is a prevalent and fatal cancer in China and other Asian countries.Epigenetic silencing of key tumor suppressor genes(TSGs) is critical to ESCC initiation and progression.Recently,many novel TSGs silenced by promoter methylation have been identified in ESCC,and these genes further serve as potential tumor markers for high-risk group stratification,early detection,and prognosis prediction.This review summarizes recent discoveries on aberrant promoter methylation of TSGs in ESCC,providing better understanding of the role of disrupted epigenetic regulation in tumorigenesis and insight into diagnostic and prognostic biomarkers for this malignancy.

引用

页数：9

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