The Role of Stem Cells in the Treatment of Cardiovascular Diseases

被引:2
|
作者
Bakinowska, Estera [1 ]
Kielbowski, Kajetan [1 ]
Boboryko, Dominika [1 ]
Bratborska, Aleksandra Wiktoria [2 ]
Olejnik-Wojciechowska, Joanna [1 ]
Rusinski, Marcin [1 ]
Pawlik, Andrzej [1 ]
机构
[1] Pomeranian Med Univ, Dept Physiol, PL-70111 Szczecin, Poland
[2] Poznan Univ Med Sci, Dept Internal Med, PL-60780 Poznan, Poland
关键词
cardiovascular diseases; stem cells; mesenchymal stem cells; induced pluripotent stem cells; ACUTE MYOCARDIAL-INFARCTION; INTEGRIN-LINKED KINASE; MESENCHYMAL STROMAL CELLS; IMPROVES CARDIAC-FUNCTION; LEFT-VENTRICULAR FUNCTION; ISCHEMIC-HEART FAILURE; BONE-MARROW-CELLS; HYPERTROPHIC CARDIOMYOPATHY; ENDOTHELIAL-CELLS; GLOBAL BURDEN;
D O I
10.3390/ijms25073901
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cardiovascular diseases (CVDs) are the leading cause of death and include several vascular and cardiac disorders, such as atherosclerosis, coronary artery disease, cardiomyopathies, and heart failure. Multiple treatment strategies exist for CVDs, but there is a need for regenerative treatment of damaged heart. Stem cells are a broad variety of cells with a great differentiation potential that have regenerative and immunomodulatory properties. Multiple studies have evaluated the efficacy of stem cells in CVDs, such as mesenchymal stem cells and induced pluripotent stem cell-derived cardiomyocytes. These studies have demonstrated that stem cells can improve the left ventricle ejection fraction, reduce fibrosis, and decrease infarct size. Other studies have investigated potential methods to improve the survival, engraftment, and functionality of stem cells in the treatment of CVDs. The aim of the present review is to summarize the current evidence on the role of stem cells in the treatment of CVDs, and how to improve their efficacy.
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页数:30
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