Immunostimulatory Effect of Moringa oleifera Extracts on Cyclophosphamide-induced Immunosuppressed Mice

被引：1
|
作者：
Pham, Anh Thi Van [1 ]
Luong, Minh Hien [2 ]
Dinh, Hang Thi Thu [1 ]
Mai, Thanh Phuong [1 ]
Trinh, Quang Vinh [1 ]
Luong, Long Hoang [3 ,4 ]
机构：
[1] Hanoi Med Univ, Dept Pharmacol, Hanoi, Vietnam
[2] Univ Sci & Technol Hanoi, Dept Life Sci, Hanoi, Vietnam
[3] Hanoi Med Univ, Ctr Gene & Prot Res, 1 Ton That Tung St, Hanoi 10000, Vietnam
[4] Natl E Hosp, Dept Allergy Immunol & Dermatol, Hanoi, Vietnam
来源：
JOURNAL OF HERBS SPICES AND MEDICINAL PLANTS | 2021年 / 27卷 / 04期
关键词：
Bioactivity; immunostimulatory activity; immunosuppression; Swiss mice;
D O I：
10.1080/10496475.2021.1934620
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
In this study, the effect of Moringa oleifera extracts were investigated on an immunosuppressed model of cyclophosphamide-induced Swiss mice. M. oleifera seed and root extracts (2.0 g kg(-1) body wt) were administered orally for 7 consecutive days; cyclophosphamide (CP) (200 mg kg(-1) i.p.) was administered by IV on the 4(th) day. Results indicated that the extracts of the M. oleifera seeds and roots ameliorated the immunosuppressive effects of CP on delayed type hypersensitivity (DTH) response, leukocyte counts, relative organ weight, IgM concentration, serum TNF-alpha assay and micro-histological images. This study demonstrated in vivo the therapeutic effect of M. oleifera on the immune response in clinical application.
引用
收藏
页码：377 / 385
页数：9
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