A Macrophage Membrane-Coated Cu-WO3-x -Hydro820 Nanoreactor for Treatment and Photoacoustic/Fluorescence Dual-Mode Imaging of Inflamed Liver Tissue

被引：2

作者：

Luo, Yanni ^{[1
]}

Li, Caiying ^{[1
]}

Ye, Fanggui ^{[1
]}

Tian, Jianniao ^{[1
]}

Tan, Xuecai ^{[2
]}

Hu, Shengqiang ^{[1
]}

Zhao, Shulin ^{[1
]}

机构：

[1] Guangxi Normal Univ, Sch Chem & Pharmaceut Sci, State Key Lab Chem & Mol Engn Med Resources, Guilin 541004, Peoples R China

[2] Guangxi Univ Nationalities, Guangxi Key Lab Chem & Engn Forest Prod, Key Lab Guangxi Coll & Univ Food Safety & Pharmace, Sch Chem & Chem Engn, Nanning 530008, Guangxi, Peoples R China

来源：

ANALYTICAL CHEMISTRY | 2024年 / 96卷 / 16期

基金：

中国国家自然科学基金;

关键词：

TOMOGRAPHY;

D O I：

10.1021/acs.analchem.4c00889

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A disease-targeting nanoplatform that integrates imaging with therapeutic activity would facilitate early diagnosis, treatment, and therapeutic monitoring. To this end, a macrophage membrane-coated Cu-WO3-x-Hydro820 (CWHM) nanoreactor was prepared. This reactor was shown to target inflammatory tissues. The reactive oxygen species (ROS) such as H2O2 and <middle dot>OH in inflammatory tissues can react with Hydro820 in the reactor to form the NIR fluorophore IR820. This process allowed photoacoustic/fluorescence dual-mode imaging of H2O2 and <middle dot>OH, and it is expected to permit visual diagnosis of inflammatory diseases. The Cu-WO3-x nanoparticles within the nanoreactor shown catalase and superoxide enzyme mimetic activity, allowing the nanoreactor to catalyze the decomposition of H2O2 and <middle dot>O-2(-) in inflammatory cells of hepatic tissues in a mouse model of liver injury, thus alleviating the oxidative stress of damaged liver tissue. This nanoreactor illustrates a new strategy for the diagnosis and treatment of hepatitis and inflammatory liver injury.

引用

页码：6483 / 6492

页数：10