Recent developments, opportunities, and challenges in the study of mRNA pseudouridylation

被引：1
|
作者：
Gilbert, Wendy V. [1 ]
机构：
[1] Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA
来源：
RNA | 2024年 / 30卷 / 05期
基金：
美国国家卫生研究院;
关键词：
mRNA modification; pseudouridine; PROFILING REVEALS; MAPPING REVEALS; IDENTIFICATION; WIDESPREAD; BINDING; YEAST;
D O I：
10.1261/rna.079975.124
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Pseudouridine is an abundant mRNA modification found in diverse organisms ranging from bacteria and viruses to multicellular plants and humans. New developments in pseudouridine profiling provide quantitative tools to map mRNA pseudouridylation sites. Sparse biochemical studies establish the potential for mRNA pseudouridylation to affect most stages of the mRNA life cycle from birth to death. This recent progress sets the stage for deeper investigations into the molecular and cellular functions of specific mRNA pseudouridines, including in disease.
引用
收藏
页码：530 / 536
页数：7
相关论文
共 50 条
  • [1] Recent developments in forward osmosis: Opportunities and challenges
    Zhao, Shuaifei
    Zou, Linda
    Tang, Chuyang Y.
    Mulcahy, Dennis
    [J]. JOURNAL OF MEMBRANE SCIENCE, 2012, 396 : 1 - 21
  • [2] Recent Developments, Challenges and Opportunities in Targeting the KRAS Pathway
    Pothuganti, Manoj Kumar
    Mitra, Sayan
    Iyer, Pravin
    Gowda, Nagaraj
    [J]. LETTERS IN DRUG DESIGN & DISCOVERY, 2023, 20 (08) : 992 - 1004
  • [3] Pancreatic cancer research: challenges, opportunities, and recent developments
    Fernandez-Zapico, ME
    Kaczynski, JA
    Urrutia, R
    [J]. CURRENT OPINION IN GASTROENTEROLOGY, 2002, 18 (05) : 563 - 567
  • [4] An overview of polyolefin foams - Opportunities, challenges and recent developments
    Park, CP
    [J]. FOAMS '99: FIRST INTERNATIONAL CONFERENCE ON THERMOPLASTIC FOAM, 1999, : 61 - 72
  • [5] Recent developments of the mainstream anammox processes: Challenges and opportunities
    Hoang Phuc Trinh
    Lee, Sang-Hoon
    Jeong, Garam
    Yoon, Hyeokjun
    Park, Hee-Deung
    [J]. JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING, 2021, 9 (04):
  • [6] Plant Protein Structuring: Recent Developments, Opportunities, and Challenges
    Don, Clyde
    van der Goot, Atze Jan
    [J]. CEREAL FOODS WORLD, 2020, 65 (04)
  • [7] Synthetic and medicinal chemistry of phthalazines: Recent developments, opportunities and challenges
    Zaib, Sumera
    Khan, Imtiaz
    [J]. BIOORGANIC CHEMISTRY, 2020, 105
  • [8] Synbiotics for Improved Human Health: Recent Developments, Challenges, and Opportunities
    Krumbeck, Janina A.
    Walter, Jens
    Hutkins, Robert W.
    [J]. ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 9, 2018, 9 : 451 - 479
  • [9] Algae as a source of renewable energy: opportunities, challenges, and recent developments
    Hussain, Javid
    Rittmann, Bruce E.
    [J]. SUSTAINABLE ENERGY & FUELS, 2023, 7 (11) : 2515 - 2544
  • [10] Considering combined exposures in risk assessment: Recent developments, opportunities and challenges
    Meek, B.
    [J]. TOXICOLOGY LETTERS, 2010, 196 : S34 - S34
12345